Neuroprotective effects of gastrodin in both in vivo and in vitro models of Parkinson's disease: Mechanisms from the perspective of oxidative stress, ferroptosis, and cellular senescence

被引：0

作者：

Li, Shanshan ^{[1
]}

Wang, Meng ^{[1
]}

Jia, Buyun ^{[1
]}

Li, Baikun ^{[1
]}

Cheng, Hui ^{[1
]}

Tian, Shasha ^{[2
]}

Li, Qinglin ^{[1
]}

机构：

[1] Anhui Univ Chinese Med, Minist Educ, Lab Xinan Med, Hefei 230038, Peoples R China

[2] Zhejiang Chinese Med Univ, Sch Pharm, Hangzhou 310053, Peoples R China

来源：

JOURNAL OF FUNCTIONAL FOODS | 2025年 / 125卷

关键词：

Parkinson's disease; Ferroptosis; Cell senescence; Gastrodin; IRON; DEATH; CELLS; DYSFUNCTION; EXPRESSION; ROTENONE; FORM;

D O I：

10.1016/j.jff.2025.106682

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Aims: To investigate the effect of GAS in PD models by regulating ferroptosis and cell senescence. Methods: MPTP or MPP+ was used to establish PD models in vivo or in vitro, and the effect of GAS was detected by behavioral analysis, immunohistochemistry and cell viability. At the same time, transmission electron microscopy, biochemical kits, Western blotting, immunofluorescence, and molecular docking were used. Results: We found that gastrodin could inhibit cell senescence in PD models. In addition, GAS was found to inhibit ferroptosis, regulate oxidative stress level, and level of ACSL4, FTH1, SLC7A11, GPX4. We also found that Ferrostatin-1 and GAS could inhibit cell senescence. The results of molecular docking and immunofluorescence showed that p53 may be an important target of GAS. After treatment with Pifithrin-alpha, the protective effect of GAS was enhanced. Conclusion: GAS inhibits cellular senescence in PD models and treats PD through a novel mechanism related to ferroptosis.

引用

页数：13

共 46 条

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