Green Identification of the Source of Pharmaceuticals by Near-Infrared (NIR) Spectroscopy and Chemometrics

被引：1

作者：

Chen, Hui ^{[1
,2
]}

Tan, Cheng ^{[3
]}

Cheng, Bin ^{[1
]}

Lin, Zan ^{[4
]}

Tan, Chao ^{[1
]}

机构：

[1] Yibin Univ, Key Lab Proc Anal & Control Sichuan Univ, Yibin 644000, Sichuan, Peoples R China

[2] Yibin Univ, Hosp, Yibin, Sichuan, Peoples R China

[3] Aba Teachers Univ, Coll Resources & Environm, Wenchuan, Sichuan, Peoples R China

[4] Sichuan Prov Orthoped Hosp, Dept Knee Sports Injury, Chengdu, Sichuan, Peoples R China

来源：

ANALYTICAL LETTERS | 2025年

关键词：

Azithromycin; counterfeit drugs; near-infrared (NIR); spectroscopy; partial least squares (PLS); ReliefF; PORTABLE RAMAN; COUNTERFEIT; SPECTROMETRY; MEDICINES; QUALITY; DRUGS;

D O I：

10.1080/00032719.2025.2460572

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The means of counterfeiting are becoming increasingly sophisticated, posing great challenges to detection technologies. A green method for differentiating the source of pharmaceuticals from different factories using portable near-infrared (NIR) spectroscopy and chemometrics is developed. A set of azithromycin tablets from different manufacturers are used in the experiments. The ReliefF-based algorithm and -partial least squares (PLS) are used for variable selection and modeling, respectively. Both full-spectrum and local models achieve 100% accuracy. It is more desirable to develop low-cost methods on a small wavelength range, which has been demonstrated to be a potential tool for drug quality supervision.

引用

页数：14

共 31 条

[21] Detection of glibenclamide adulterated in antidiabetic Chinese patent medicine by attenuated total reflectance -infrared spectroscopy and chemometrics [J].

Tan, Chao ;

Chen, Hui ;

Lin, Zan .

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2021, 255

[22] Screening of unapproved drugs using portable Raman spectroscopy [J].

Tondepu, Chaitanya ;

Toth, Roxana ;

Navin, Chelliah V. ;

Lawson, Latevi S. ;

Rodriguez, Jason D. .

ANALYTICA CHIMICA ACTA, 2017, 973 :75-81

[23] Relief-based feature selection: Introduction and review [J].

Urbanowicz, Ryan J. ;

Meeker, Melissa ;

La Cava, William ;

Olson, Randal S. ;

Moore, Jason H. .

JOURNAL OF BIOMEDICAL INFORMATICS, 2018, 85 :189-203

[24] Dose-to-dose variations with single packages of counterfeit medicines and adulterated dietary supplements as a potential source of false negatives and inaccurate health risk assessments [J].

Venhuis, B. J. ;

Zwaagstra, M. E. ;

Keizers, P. H. J. ;

de Kaste, D. .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 89 :158-165

[25] Rapid detection of protein content in rice based on Raman and near-infrared spectroscopy fusion strategy combined with characteristic wavelength selection [J].

Wang, Zhiqiang ;

Liu, Jinming ;

Zeng, Changhao ;

Bao, Changhao ;

Li, Zhijiang ;

Zhang, Dongjie ;

Zhen, Feng .

INFRARED PHYSICS & TECHNOLOGY, 2023, 129

[26] PLS-regression:: a basic tool of chemometrics [J].

Wold, S ;

Sjöström, M ;

Eriksson, L .

CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 2001, 58 (02) :109-130

[27] Fast detection of volatile fatty acids in biogas slurry using NIR spectroscopy combined with feature wavelength selection [J].

Xu, Yonghua ;

Liu, Jinming ;

Sun, Yong ;

Chen, Shaopeng ;

Miao, Xinying .

SCIENCE OF THE TOTAL ENVIRONMENT, 2023, 857

[28] Research on Rapid Determination of Lignocellulosic Contents in Corn Stover Using Near Infrared Spectroscopy Based on Spectral Intervals Selection [J].

Yong-Hua, X. U. ;

Na, W. A. N. G. ;

Jin-Ming, L. J. U. .

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2022, 50 (10) :1587-1596

[29] Raman spectroscopy and mapping technique for the identification of expired drugs [J].

Zhang, Shuoyang ;

Chen, Hui ;

Li, Ruiyun ;

Yu, Zhiguo ;

Lu, Feng .

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2020, 224

[30] Evaluation of coating uniformity for the digestion-aid tablets by portable near-infrared spectroscopy [J].

Zhong, Zhijian ;

Liu, Xuhai ;

Luo, Xiaorong ;

Zhu, Yewei ;

Wang, Shuai ;

Huang, Yue .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2022, 622

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