Comparison of the Anesthetic Effects of Alfaxalone Combined with Xylazine or Dexmedetomidine in Captive Formosa Serows (Capricornis swinhoei)

被引：0

作者：

Chang, Li-Jen ^{[1
]}

Ishihara, Toshitsugu ^{[1
]}

Lien, Chen-Yeh ^{[2
]}

Chen, Kuan-Sheng ^{[3
,4
]}

机构：

[1] Virginia Maryland Coll Vet Med, Dept Small Anim Clin Sci, Blacksburg, VA 24061 USA

[2] Taipei Zoo, Anim Med Ctr, Taipei 11656, Taiwan

[3] Natl Chung Hsing Univ, Coll Vet Med, Dept Vet Med, Taichung 40227, Taiwan

[4] Natl Chung Hsing Univ, Vet Med Teaching Hosp, Coll Vet Med, Taichung 40227, Taiwan

来源：

ANIMALS | 2025年 / 15卷 / 03期

关键词：

alfaxalone; anesthesia; Formosan serow (Capricornis swinhoei); hypoventilation; hypoxemia; INTRAMUSCULAR ALFAXALONE; MEDETOMIDINE; DOGS; PROPOFOL; KETAMINE; IMMOBILIZATION; INFUSION; FENTANYL;

D O I：

10.3390/ani15030307

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Formosan serows are an endemic species in Taiwan. Alfaxalone, a gamma-aminobutyric acid(A) agonist, induces or maintains anesthesia in various veterinary species with reported potential adverse effects of respiratory depression and tachycardia. alpha 2-Adrenoceptor agonists exert sedative and muscle relaxation effects, along with substantial cardiovascular adverse effects. Here, we aimed to evaluate the anesthetic effects of alfaxalone combined with xylazine or dexmedetomidine (AX vs. AD, respectively) in Formosan serows. In this randomized, masked study, AX was administered to four serows, and AD was administered to five serows intramuscularly via blow dart. The time and score of induction and recovery were recorded. Post-intubation, isoflurane was administered for maintenance anesthesia. Heart rate (HR), respiratory rate (RR), peripheral saturation of oxygenation (SpO(2)), rectal temperature (RT), and end-tidal CO2 (EtCO2) were recorded every five to eight minutes. Atipamezole and tolazoline were administered to antagonize dexmedetomidine and xylazine post-procedure, respectively. Both combinations allowed smooth induction and recovery. The AD group exhibited significantly lower HR and SpO(2) and significantly higher RT and EtCO2 than the AX group (both p < 0.01). The AD-treated serows exhibited notable muscle rigidity after induction and significant hypoventilation and hypoxemia during the procedure. Although alfaxalone combined with dexmedetomidine or xylazine can produce satisfactory induction and recovery in Formosa serows, notable hypoxemia and hypoventilation are induced by the alfaxalone-dexmedetomidine combination compared to the alfaxalone-xylazine combination.

引用

页数：14

共 38 条

[1]

Lue K.Y., A preliminary study on the ecology of Formosan serow Capricornis crispus swinhoei, The Biology and Management of Capricornis and Related Mountain Antelopes, pp. 125-133, (1987)

[2]

Moberg G.P., Biological response to stress: Implications for animal welfare, The Biology of Animal Stress: Basic Principles and Implications for Animal Welfare, pp. 1-21, (2000)

[3]

Ferre P.J., Pasloske K., Whittem T., Ranasinghe M.G., Li Q., Lefebvre H.P., Plasma pharmacokinetics of alfaxalone in dogs after an intravenous bolus of Alfaxan-CD RTU, Vet. Anaesth. Analg, 33, pp. 229-236, (2006)

[4]

Hall L.W., Althesin in the larger animal, Postgrad. Med. J, 48, pp. 55-58, (1972)

[5]

Cottrell G.A., Lambert J.J., Peters J.A., Modulation of GABAA receptor activity by alphaxalone, Br. J. Pharmacol, 90, pp. 491-500, (1987)

[6]

Dzikiti B.T., Ndawana P.S., Zeiler G., Ferreira J.P., Dzikiti L.N., Determination of the minimum infusion rate of alfaxalone during its co-administration with fentanyl at three different doses by constant rate infusion intravenously in goats, Vet. Anaesth. Analg, 43, pp. 316-325, (2016)

[7]

Dzikiti T., Ndawana P., Zeiler G., Bester L., Dzikiti L., Determination of the minimum infusion rate of alfaxalone during its co-administration with midazolam in goats, Vet. Rec. Open, 2, (2015)

[8]

Dzikiti T.B., Zeiler G.E., Dzikiti L.N., Garcia E.R., The effects of midazolam and butorphanol, administered alone or combined, on the dose and quality of anaesthetic induction with alfaxalone in goats, J. S. Afr. Vet. Assoc, 85, pp. 1-8, (2014)

[9]

Cremer J., Ricco C.H., Cardiovascular, respiratory and sedative effects of intramuscular alfaxalone, butorphanol and dexmedetomidine compared with ketamine, butorphanol and dexmedetomidine in healthy cats, J. Feline Med. Surg, 20, pp. 973-979, (2018)

[10]

Granfone M.C., Walker J.M., Smith L.J., Evaluation of an intramuscular butorphanol and alfaxalone protocol for feline blood donation: A pilot study, J. Feline Med. Surg, 20, pp. 793-798, (2018)

← 1 2 3 4 →