Evaluation of Hematological and Biochemical Parameters that Predict the No-reflow Phenomenon in Patients Undergoing Primary Percutaneous Coronary Intervention

被引：0
作者：
Aydemir, Selim [1 ]
Aydin, Sidar Siyar [2 ]
Altinkaya, Onur [1 ]
Aksakal, Emrah [1 ]
Ozmen, Murat [1 ]
机构：
[1] Univ Hlth Sci, Erzurum City Hosp, Dept Cardiol, TR-25080 Erzurum, Turkiye
[2] Ataturk Univ, Fac Med, Dept Cardiol, Erzurum, Turkiye
来源：
ANGIOLOGY | 2025年
关键词：
acute coronary syndrome; no-reflow phenomenon; primary percutaneous coronary intervention; ELEVATION MYOCARDIAL-INFARCTION; TO-LYMPHOCYTE RATIO; CELL DISTRIBUTION WIDTH; ADVERSE CARDIAC EVENTS; LONG-TERM OUTCOMES; MICROVASCULAR OBSTRUCTION; NEUTROPHIL/LYMPHOCYTE RATIO; D-DIMER; NEUTROPHIL; MORTALITY;
D O I：
10.1177/00033197251320141
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Acute coronary syndromes (ACS) are one of the most common causes of morbidity and mortality worldwide. Primary percutaneous coronary intervention (pPCI) is the main treatment strategy to restore myocardial perfusion. However, the no-reflow phenomenon (NRP) may block coronary flow. The present study focused on assessing and contrasting predictive parameters for NRP in ACS patients. Our research is a retrospective analysis. We assessed the parameters significantly associated with NRP using Cox regression and Receiver operating characteristic (ROC) Curve analysis. The study included 5122 patients who met the criteria. The average age of the patients was 63.9 + 13.2, and 74.4% were male. It was observed that NRP developed in 1.8% of all patients. Age, hemoglobin (Hb), white blood cell (WBC), glucose and low density lipoprotein cholesterol (LDL-C) were determined to be independent predictors of NRP. The power of these parameters to predict NRP was similar, and WBC was the most predictive (Area Under Curve (AUC): 0.605 95% CI: 0.539-0.671, P = .001). We believe that the use of these simple, practical, and routinely used hematological and biochemical parameters will help us predict the risk of developing NRP before pPCI. This information should improve management.
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页数：11
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共 95 条
[1]  
Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017, Lancet, 392, (2018)
[2]  
Timmis A., Vardas P., Townsend N., Et al., European Society of Cardiology: cardiovascular disease statistics 2021, Eur Heart J, 43, (2022)
[3]  
Byrne R.A., Rossello X., Coughlan J.J., Et al., 2023 ESC Guidelines for the management of acute coronary syndromes, Eur Heart J, 44, (2023)
[4]  
Kaur G., Baghdasaryan P., Natarajan B., Et al., Pathophysiology, diagnosis, and management of coronary no-reflow phenomenon, Int J Angiol, 30, pp. 15-21, (2021)
[5]  
Rezkalla S.H., Stankowski R.V., Hanna J., Kloner R.A., Management of no-reflow phenomenon in the catheterization laboratory, JACC Cardiovasc Interv, 10, (2017)
[6]  
Galasso G., Schiekofer S., D'Anna C., Et al., No-reflow phenomenon: pathophysiology, diagnosis, prevention, and treatment. A review of the current literature and future perspectives, Angiology, 65, (2014)
[7]  
Wu X., Mintz G.S., Xu K., Et al., The relationship between attenuated plaque identified by intravascular ultrasound and no-reflow after stenting in acute myocardial infarction: the HORIZONS-AMI (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction) trial, JACC Cardiovasc Interv, 4, pp. 495-502, (2011)
[8]  
Bekkers S.C., Yazdani S.K., Virmani R., Waltenberger J., Microvascular obstruction: underlying pathophysiology and clinical diagnosis, J Am Coll Cardiol, 55, (2010)
[9]  
Chandrashekhar Y., Alexander T., Mullasari A., Et al., Resource and infrastructure-appropriate management of ST-segment elevation myocardial infarction in low- and middle-income countries, Circulation, 141, (2020)
[10]  
Refaat H., Tantawy A., Gamal A.S., Radwan H., Novel predictors and adverse long-term outcomes of No-reflow phenomenon in patients with acute ST elevation myocardial infarction undergoing primary percutaneous coronary intervention, Indian Heart J, 73, pp. 35-43, (2021)
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