The advancement of nanosystems for drug delivery in the prevention and treatment of dental caries

被引：0
作者：
Du, Han [1 ]
Wang, Zheng [1 ]
Long, Shenglan [1 ]
Li, Yiding [1 ]
Yang, Deqin [1 ,2 ,3 ,4 ]
机构：
[1] Chongqing Med Univ, Stomatol Hosp, Chongqing Key Lab Oral Dis, Chongqing, Peoples R China
[2] Shanghai Stomatol Hosp, Dept Conservat Dent & Endodont, Shanghai, Peoples R China
[3] Fudan Univ, Sch Stomatol, Shanghai, Peoples R China
[4] Fudan Univ, Shanghai Key Lab Craniomaxillofacial Dev & Dis, Shanghai, Peoples R China
来源：
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2025年 / 15卷
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
dental caries; biofilm; nanosystems for drug delivery; remineralization; antibacterial agents; MESOPOROUS SILICA NANOPARTICLES; STREPTOCOCCUS-MUTANS; SILVER NANOPARTICLES; ANTI-BIOFILM; IN-VITRO; CHLORHEXIDINE; CHITOSAN; REMINERALIZATION; AMELOGENIN; EFFICACY;
D O I：
10.3389/fcimb.2025.1546816
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The dental caries remains a globally prevalent disease. Although its incidence has decrease due to enhancements in sanitation policies and public health measures, the treatment and prevention of dental caries still pose significant challenges. Within the oral cavity, traditional drug delivery systems suffer from limitation such as inadequate tissue penetration, short duration of action at target site, and low specificity, which minimally affect the prevention and treatment of dental caries. Consequently, nanosystem for drug delivery, offering enhanced drug stability, solubility, and bio-availability while reducing side effects, garnering attention increasing attention in the fight against dental caries. Therefore, this review examines the role of nanosystems for drug delivery in combating dental caries by inhibiting bacteria survival, biofilm formation, demineralization, and promoting remineralization, and exploring their potential to become the mainstream means of prevention and treatment of dental caries in future.
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页数：17
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