Synthesis of phosphate-substituted near-infrared dyes for photoacoustic imaging and photothermal therapy

被引：0
作者：
Ding, Xiuqian [1 ]
Wang, Yong [1 ]
Nan, Jingxi [2 ]
Wu, Xue [3 ]
Zhou, Xin [1 ]
机构：
[1] Qingdao Univ, Coll Chem & Chem Engn, Qingdao, Peoples R China
[2] Comprehens Tech Serv Ctr Yanji Customs, Yanji, Peoples R China
[3] Yanbian Univ, Dept Chem, Yanji, Peoples R China
来源：
DYES AND PIGMENTS | 2025年 / 236卷
关键词：
Photothermal therapy; Near-infrared dyes; Photoacoustic imaging;
D O I：
10.1016/j.dyepig.2025.112663
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Photothermal therapy (PTT) can effectively ablate hypoxic tumors in deep issue under the near-infrared (NIR) irradiation. The development of novel NIR photothermal agents with high molar absorption coefficient and photothermal conversion efficiency is highly demanded. In this work, two phosphate-substituted xanthene dyes (POM and P7) were synthesized, and their stability and photothermal conversion efficiency were investigated. Both of them showed board absorption around 700 nm in the aqueous solution. In comparison with the rigid POM, P7 with flexible and twisted core displayed a higher photothermal conversion efficiency. The nanoparticle encapsulated in amphiphilic polymers (P7 NPs) was further used in the photoacoustic imaging-guided photo- thermal therapy in vivo.
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页数：7
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