Future Directions in Depression Prevention

Objective: Rising rates of mental illness in young people over recent decades are a trend that represents a wake-up call across the globe. The causes of this increase are not known. We also know little about effective interventions or implementation strategies to prevent depression in either youth or adults. The need for the prevention of mental ill health represents an outstanding research opportunity for our field. Method: This conceptual article identifies current challenges in our field, provides potential solutions, and suggests the most promising avenues for future solutions and how we might investigate them. Results: Key challenges include the following: poor implementation with low fidelity; methodological challenges related to appropriate sampling, time frames, interventions, and active controls; and lack of fit between interventions and their context. Potential solutions include the following: supplementing trials with evidence from large-scale epidemiological studies, establishing prevention models that work at scale including those that address social determinants and show effectiveness in low- and middle-income countries, building capacity in methods, and strengthening geographically dispersed networks of prevention researchers and practitioners. Conclusions: There are major challenges in conducting prevention research and demonstrating effects. New perspectives and collaborations are needed to overcome existing barriers.