Prognostic value of neutrophil to lymphocyte ratio for patients with bladder cancer undergoing radical cystectomy: a systematic review and meta-analysis

被引：0
作者：
Chen, Zhan [1 ]
Zhang, Yao [1 ]
Chen, Telei [2 ]
机构：
[1] Cixilntegrated Tradit Chinese & Western Med Med, Dept Urol, Ningbo, Zhejiang, Peoples R China
[2] Ningbo Yinzhou 2 Hosp, Dept Urol, Ningbo, Zhejiang, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
关键词：
neutrophil; lymphocyte; NLR; bladder cancer; radical cystectomy; meta-analysis; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; UROTHELIAL CARCINOMA; PREDICTS; NLR; EPIDEMIOLOGY; SURVIVAL; OUTCOMES; IMMUNE; CELLS; INDEX;
D O I：
10.3389/fonc.2024.1463173
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objectives: This study evaluated the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) for survival outcomes in bladder cancer patients treated with radical cystectomy. Methods: Studies assessing NLR's prognostic significance for bladder cancer after radical cystectomy were identified from PubMed, Embase, Web of Science, and Cochrane databases until April 2024. Survival outcomes analyzed included overall survival (OS), disease-free survival (DFS), relapse-free survival (RFS), cancer-specific survival (CSS), and progression-free survival (PFS). Results: The meta-analysis comprised 15 cohort studies with 8,448 patients. Multivariate analysis showed significantly shorter OS, CSS, DFS, and RFS in the high NLR group compared to the low NLR group. However, no significant difference in PFS was observed between the groups. Conclusions: NLR serves as an independent prognostic indicator for bladder cancer patients undergoing radical cystectomy, with elevated NLR associated with poorer survival. Further large-scale, prospective studies are warranted to validate the relationship between NLR and prognosis in bladder cancer.
引用
收藏
页数：10
相关论文
共 66 条
[1]   Usefulness of the Neutrophil-to-Lymphocyte Ratio in Predicting Short- and Long-Term Mortality in Breast Cancer Patients [J].
Azab, Basem ;
Bhatt, Vijaya R. ;
Phookan, Jaya ;
Murukutla, Srujitha ;
Kohn, Nina ;
Terjanian, Terenig ;
Widmann, Warren D. .
ANNALS OF SURGICAL ONCOLOGY, 2012, 19 (01) :217-224
[2]   European Association of Urology Guidelines on Non-muscle-invasive Bladder Cancer (Ta, T1, and Carcinoma in Situ) [J].
Babjuk, Marko ;
Burger, Maximilian ;
Capoun, Otakar ;
Cohen, Daniel ;
Comperat, Eva M. ;
Escrig, Jose L. Dominguez ;
Gontero, Paolo ;
Liedberg, Fredrik ;
Masson-Lecomte, Alexandra ;
Mostafid, A. Hugh ;
Palou, Joan ;
van Rhijn, Bas W. G. ;
Roupret, Morgan ;
Shariat, Shahrokh F. ;
Seisen, Thomas ;
Soukup, Viktor ;
Sylvester, Richard J. .
EUROPEAN UROLOGY, 2022, 81 (01) :75-94
[3]   Th17-inducing autologous dendritic cell vaccination promotes antigen-specific cellular and humoral immunity in ovarian cancer patients [J].
Block, Matthew S. ;
Dietz, Allan B. ;
Gustafson, Michael P. ;
Kalli, Kimberly R. ;
Erskine, Courtney L. ;
Youssef, Bahaaeldin ;
Vijay, Geraldine V. ;
Allred, Jacob B. ;
Pavelko, Kevin D. ;
Strausbauch, Michael A. ;
Lin, Yi ;
Grudem, Megan E. ;
Jatoi, Aminah ;
Klampe, Carolyn M. ;
Wahner-Hendrickson, Andrea E. ;
Weroha, S. John ;
Glaser, Gretchen E. ;
Kumar, Amanika ;
Langstraat, Carrie L. ;
Solseth, Mary L. ;
Deeds, Michael C. ;
Knutson, Keith L. ;
Cannon, Martin J. .
NATURE COMMUNICATIONS, 2020, 11 (01)
[4]  
Castelao JE, 2000, BRIT J CANCER, V82, P1364
[5]  
Celik O, 2016, EUR REV MED PHARMACO, V20, P652
[6]   The gene expression profile of inflammatory, hypoxic and metabolic genes predicts the metastatic spread of human head and neck squamous cell carcinoma [J].
Clatot, Florian ;
Gouerant, Sophie ;
Mareschal, Sylvain ;
Cornic, Marie ;
Berghian, Anca ;
Choussy, Olivier ;
El Ouakif, Faissal ;
Francois, Arnaud ;
Benard, Magalie ;
Ruminy, Philippe ;
Picquenot, Jean-Michel ;
Jardin, Fabrice .
ORAL ONCOLOGY, 2014, 50 (03) :200-207
[7]   Current best practice for bladder cancer: a narrative review of diagnostics and treatments [J].
Comperat, Eva ;
Amin, Mahul B. ;
Cathomas, Richard ;
Choudhury, Ananya ;
De Santis, Maria ;
Kamat, Ashish ;
Stenzl, Arnulf ;
Thoeny, Harriet C. ;
Witjes, Johannes Alfred .
LANCET, 2022, 400 (10364) :1712-1721
[8]   Lymphocyte-to-monocyte ratio and neutrophil-to-lymphocyte ratio as biomarkers for predicting lymph node metastasis and survival in patients treated with radical cystectomy [J].
D'Andrea, David ;
Moschini, Marco ;
Gust, Kilian M. ;
Abufaraj, Mohammad ;
Ozsoy, Mehmet ;
Mathieu, Romain ;
Soria, Francesco ;
Briganti, Alberto ;
Roupret, Morgan ;
Karakiewicz, Pierre I. ;
Shariat, Shahrokh F. .
JOURNAL OF SURGICAL ONCOLOGY, 2017, 115 (04) :455-461
[9]   Efficacy of Different Bacillus of Calmette-Guerin (BCG) Strains on Recurrence Rates among Intermediate/High-Risk Non-Muscle Invasive Bladder Cancers (NMIBCs): Single-Arm Study Systematic Review, Cumulative and Network Meta-Analysis [J].
Del Giudice, Francesco ;
Asero, Vincenzo ;
Bologna, Eugenio ;
Scornajenghi, Carlo Maria ;
Carino, Dalila ;
Dolci, Virginia ;
Viscuso, Pietro ;
Salciccia, Stefano ;
Sciarra, Alessandro ;
D'Andrea, David ;
Pradere, Benjamin ;
Moschini, Marco ;
Mari, Andrea ;
Albisinni, Simone ;
Krajewski, Wojciech ;
Szydelko, Tomasz ;
Malkiewicz, Bartosz ;
Nowak, Lukasz ;
Laukhtina, Ekaterina ;
Gallioli, Andrea ;
Mertens, Laura S. ;
Marcq, Gautier ;
Cimadamore, Alessia ;
Afferi, Luca ;
Soria, Francesco ;
Mori, Keiichiro ;
Tully, Karl Heinrich ;
Pichler, Renate ;
Ferro, Matteo ;
Tataru, Octavian Sabin ;
Autorino, Riccardo ;
Crivellaro, Simone ;
Crocetto, Felice ;
Busetto, Gian Maria ;
Basran, Satvir ;
Eisenberg, Michael L. ;
Chung, Benjamin Inbeh ;
De Berardinis, Ettore .
CANCERS, 2023, 15 (07)
[10]   Bladder cancer [J].
Dyrskjot, Lars ;
Hansel, Donna E. ;
Efstathiou, Jason A. ;
Knowles, Margaret A. ;
Galsky, Matthew D. ;
Teoh, Jeremy ;
Theodorescu, Dan .
NATURE REVIEWS DISEASE PRIMERS, 2023, 9 (01) :59
1234567