Narrative Review: Advancing Dysbiosis Treatment in Onco-Hematology with Microbiome-Based Therapeutic Approach

被引：3
作者：
Biennier, Salome [1 ]
Fontaine, Mathieu [1 ]
Duquenoy, Aurore [1 ]
Schwintner, Carole [1 ]
Dore, Joel [2 ]
Corvaia, Nathalie [1 ]
机构：
[1] MaaT Pharm, F-69007 Lyon, France
[2] Univ Paris Saclay, INRAE, MetaGenoPolis, AgroParisTech,MICALIS, F-78350 Jouy En Josas, France
来源：
MICROORGANISMS | 2024年 / 12卷 / 11期
关键词：
dysbiosis; GvHD; onco-hematology; donor-derived products; full ecosystem; VERSUS-HOST-DISEASE; GUT MICROBIOTA; INTESTINAL MICROBIOTA; ACUTE GVHD; MODULATION; TRANSPLANTATION; CANCER; CHEMOTHERAPY; MORTALITY; EFFICACY;
D O I：
10.3390/microorganisms12112256
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
This review explores the complex relationship between gut dysbiosis and hematological malignancies, focusing on graft-versus-host disease (GvHD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. We discuss how alterations in microbial diversity and composition can influence disease development, progression, and treatment outcomes in blood cancers. The mechanisms by which the gut microbiota impacts these conditions are examined, including modulation of immune responses, production of metabolites, and effects on intestinal barrier function. Recent advances in microbiome-based therapies for treating and preventing GvHD are highlighted, with emphasis on full ecosystem standardized donor-derived products. Overall, this review underscores the growing importance of microbiome research in hematology-oncology and its potential to complement existing treatments and improve outcomes for thousands of patients worldwide.
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页数：25
相关论文
共 165 条
[1]   Microbiome and Human Health: Current Understanding, Engineering, and Enabling Technologies [J].
Aggarwal, Nikhil ;
Kitano, Shohei ;
Puah, Ginette Ru Ying ;
Kittelmann, Sandra ;
Hwang, In Young ;
Chang, Matthew Wook .
CHEMICAL REVIEWS, 2023, 123 (01) :31-72
[2]   Influence of gut microbiome on multiple myeloma: friend or foe? [J].
Ahmed, Nausheen ;
Ghannoum, Mahmoud ;
Gallogly, Molly ;
de Lima, Marcos ;
Malek, Ehsan .
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 (01)
[3]   Preliminary profile of the gut microbiota from amerindians in the Brazilian amazon experiencing a process of transition to urbanization [J].
Alencar, Rodrigo M. ;
Martinez, Jose G. ;
Machado, Valeria N. ;
Alzate, Juan F. ;
Ortiz-Ojeda, Cinthya P. ;
Matias, Rosiane R. ;
Benzaquem, Denise C. ;
Santos, Maria C. F. ;
Assuncao, Enedina N. ;
Lira, Evelyn C. ;
Astolfi-Filho, Spartaco ;
Hrbek, Tomas ;
Farias, Izeni P. ;
Fantin, Cleiton .
BRAZILIAN JOURNAL OF MICROBIOLOGY, 2024, 55 (03) :2345-2354
[4]   Gut microbiota modulation of chemotherapy efficacy and toxicity [J].
Alexander, James L. ;
Wilson, Ian D. ;
Teare, Julian ;
Marchesi, Julian R. ;
Nicholson, Jeremy K. ;
Kinross, James M. .
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2017, 14 (06) :356-365
[5]   Impact of the gut microbiome on the genome and epigenome of colon epithelial cells: contributions to colorectal cancer development [J].
Allen, Jawara ;
Sears, Cynthia L. .
GENOME MEDICINE, 2019, 11 (1)
[6]   A unified catalog of 204,938 reference genomes from the human gut microbiome [J].
Almeida, Alexandre ;
Nayfach, Stephen ;
Boland, Miguel ;
Strozzi, Francesco ;
Beracochea, Martin ;
Shi, Zhou Jason ;
Pollard, Katherine S. ;
Sakharova, Ekaterina ;
Parks, Donovan H. ;
Hugenholtz, Philip ;
Segata, Nicola ;
Kyrpides, Nikos C. ;
Finn, Robert D. .
NATURE BIOTECHNOLOGY, 2021, 39 (01) :105-114
[7]   The gut dysbiosis-cancer axis: illuminating novel insights and implications for clinical practice [J].
Asseri, Amer H. ;
Bakhsh, Tahani ;
Abuzahrah, Samah Sulaiman ;
Ali, Sajad ;
Rather, Irfan A. .
FRONTIERS IN PHARMACOLOGY, 2023, 14
[8]   The Gastrointestinal Microbiome: A Review [J].
Barko, P. C. ;
McMichael, M. A. ;
Swanson, K. S. ;
Williams, D. A. .
JOURNAL OF VETERINARY INTERNAL MEDICINE, 2018, 32 (01) :9-25
[9]  
Belizario Jose E, 2018, Exp Suppl, V109, P459, DOI 10.1007/978-3-319-74932-7_13
[10]   Homeostatic Immunity and the Microbiota [J].
Belkaid, Yasmine ;
Harrison, Oliver J. .
IMMUNITY, 2017, 46 (04) :562-576
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