Surface plasmon resonance biosensors and their medical applications

被引：12

作者：

Springer, Tomas ^{[1
]}

Bockova, Marketa ^{[1
]}

Slaby, Jiri ^{[1
]}

Sohrabi, Foozieh ^{[1
]}

Capkova, Magdalena ^{[1
]}

Homola, Jiri ^{[1
]}

机构：

[1] Czech Acad Sci, Inst Photon & Elect, Chaberska 1014-57, Prague 18251, Czech Republic

来源：

BIOSENSORS & BIOELECTRONICS | 2025年 / 278卷

关键词：

Surface plasmon resonance biosensor; Plasmonic affinity biosensor; Optical biosensor; Medical diagnostics; Biomarker; LABEL-FREE DETECTION; NANOPLASMONIC BIOSENSOR; BLOOD; ENHANCEMENT; SENSORS; PROTEIN; ASSAY;

D O I：

10.1016/j.bios.2025.117308

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Surface plasmon resonance (SPR) biosensors are an advanced optical biosensing technology that has been widely used in molecular biology for the investigation of biomolecular interactions and in bioanalytics for the detection of biological species. This work aims to review progress in the development of SPR biosensors for medical diagnostics, focusing mainly on advances in optical platforms and assays enabling analysis of complex biological matrices. Applications of SPR biosensors for the detection of medically relevant analytes, such as nucleic acids, proteins, exosomes, viruses, bacteria, and circulating tumor cells, are also reviewed. The detection performance of current SPR biosensors is discussed, and routes for improving performance and expanding applications of SPR biosensors in medical diagnostics are outlined.

引用

页数：15

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