Light-triggered release of lenalidomide with fluorescent indication for inhibition of COX-2 enzyme activity in cancer cells

被引：1

作者：

Liu, Ming ^{[1
]}

Li, Yajing ^{[1
]}

Wang, Fang ^{[1
]}

Lu, Sheng ^{[1
]}

Jiang, Long ^{[2
]}

Chen, Xiaoqiang ^{[1
]}

机构：

[1] Nanjing Tech Univ, Coll Chem Engn, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, State Key Lab Mat Oriented Chem Engn, Nanjing 211816, Peoples R China

[2] Ganjiang Chinese Med Innovat Ctr, Nanchang 330000, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2025年 / 61卷 / 35期

关键词：

N-2,4-DINITROPHENYLAMINO-ACIDS; MANAGEMENT;

D O I：

10.1039/d5cc00695c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this work, we have developed a Sanger's reagent-based photocage, LNDA-NBD-Sanger, which releases the caged COX-2 inhibitor, lenalidomide (LNDA), under 400 nm UV irradiation while producing a fluorescent signal from the activated nitrobenzoxadiazole (NBD) derivative, realizing the monitoring of LNDA release in cancer cells and light-controlled anti-cancer therapy.

引用

页码：6518 / 6521

页数：4