Light-triggered release of lenalidomide with fluorescent indication for inhibition of COX-2 enzyme activity in cancer cells

被引：0
|
作者：
Liu, Ming [1 ]
Li, Yajing [1 ]
Wang, Fang [1 ]
Lu, Sheng [1 ]
Jiang, Long [2 ]
Chen, Xiaoqiang [1 ]
机构：
[1] Nanjing Tech Univ, Coll Chem Engn, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, State Key Lab Mat Oriented Chem Engn, Nanjing 211816, Peoples R China
[2] Ganjiang Chinese Med Innovat Ctr, Nanchang 330000, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2025年
关键词：
N-2,4-DINITROPHENYLAMINO-ACIDS; MANAGEMENT;
D O I：
10.1039/d5cc00695c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this work, we have developed a Sanger's reagent-based photocage, LNDA-NBD-Sanger, which releases the caged COX-2 inhibitor, lenalidomide (LNDA), under 400 nm UV irradiation while producing a fluorescent signal from the activated nitrobenzoxadiazole (NBD) derivative, realizing the monitoring of LNDA release in cancer cells and light-controlled anti-cancer therapy.
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页数：4
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