Triple inhaler therapy in adolescents and adults with moderate or severe persistent asthma

被引：0

作者：

L'Eplattenier, Mark ^{[1
]}

Pontrelli, Gina ^{[1
]}

Loscalzo, Carina ^{[1
]}

机构：

[1] Hofstra Univ, PA program, Hempstead, NY 11549 USA

来源：

JAAPA-JOURNAL OF THE AMERICAN ACADEMY OF PHYSICIAN ASSISTANTS | 2025年 / 38卷 / 01期

关键词：

asthma; triple therapy; long-acting antimuscarinic agents; phenotype; FeNO; LAMAs; INADEQUATELY CONTROLLED ASTHMA; OBSTRUCTIVE PULMONARY-DISEASE; GLOBAL BURDEN;

D O I：

10.1097/01.JAA.0000000000000153

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Expert guidelines, meta-analyses, and multiple randomized controlled trials have demonstrated the effectiveness of long-acting inhaled antimuscarinic agents (LAMAs) as an additive medication for patients with poorly controlled moderate or severe persistent asthma. LAMAs play an essential role in blocking acetylcholine binding to muscarinic receptors and reducing bronchoconstriction and mucus production. By adding this medication to other combination inhalers, patients can use a triple inhaler to improve FEV1 values and reduce exacerbations.

引用

收藏

页码：e13 / e15

页数：3

相关论文

共 25 条

[1]

[Anonymous], MOST RECENT NATL AST

[2]

[Anonymous], About us

[3] Comparison of National and Global Asthma Management Guiding Documents [J].

Baker, Joyce A. ;

Houin, Paul R. .

RESPIRATORY CARE, 2023, 68 (01) :114-128

[4]

Gill R., 2022, University of Lynchburg DMSc Doctoral Project Assignment Repository, V4

[5]

Hasan AAA., 2020, Matrix Sci Medica, V4, P112

[6] Global burden of medication non-adherence in chronic obstructive pulmonary disease (COPD) and asthma: a narrative review of the clinical and economic case for smart inhalers [J].

Jansen, Evalyne M. ;

van de Hei, Susanne J. ;

Dierick, Boudewijn J. H. ;

Kerstjens, Huib A. M. ;

Kocks, Janwillem W. H. ;

van Boven, Job F. M. .

JOURNAL OF THORACIC DISEASE, 2021, 13 (06) :3846-3864

[7] Once-daily, single-inhaler mometasone-indacaterol-glycopyrronium versus mometasone-indacaterol or twice-daily fluticasone-salmeterol in patients with inadequately controlled asthma (IRIDIUM): a randomised, double-blind, controlled phase 3 study [J].

Kerstjens, Huib A. M. ;

Maspero, Jorge ;

Chapman, Kenneth R. ;

van Zyl-Smit, Richard N. ;

Hosoe, Motoi ;

Tanase, Ana-Maria ;

Lavecchia, Catherine ;

Pethe, Abhijit ;

Shu, Xu ;

D'Andrea, Peter .

LANCET RESPIRATORY MEDICINE, 2020, 8 (10) :1000-1012

[8] Triple vs Dual Inhaler Therapy and Asthma Outcomes in Moderate to Severe Asthma A Systematic Review and Meta-analysis [J].

Kim, Lisa H. Y. ;

Saleh, Carol ;

Whalen-Browne, Anna ;

O'Byrne, Paul M. ;

Chu, Derek K. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2021, 325 (24) :2466-2479

[9] FeNO in Asthma [J].

Loewenthal, Lola ;

Menzies-Gow, Andrew .

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, 2022, 43 (05) :635-645

[10] Understanding the role of long-acting muscarinic antagonists in asthma treatment [J].

Muiser, Susan ;

Gosens, Reinoud ;

van den Berge, Maarten ;

Kerstjens, Huib A. M. .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2022, 128 (04) :352-360