Early decrease of T-bet plus B cells during subcutaneous belimumab predicts response to therapy in systemic lupus erythematosus patients

被引：0

作者：

La Gualana, Francesca ^{[1
]}

Olivieri, Giulio ^{[2
]}

Petriti, Begi ^{[1
]}

Picciariello, Licia ^{[3
]}

Natalucci, Francesco ^{[3
]}

Sciannamea, Maddalena ^{[1
]}

Gragnani, Laura ^{[4
]}

Basile, Umberto ^{[5
]}

Casato, Milvia ^{[1
]}

Spinelli, Francesca Romana ^{[3
]}

Stefanini, Lucia ^{[1
]}

Basili, Stefania ^{[1
]}

Visentini, Marcella ^{[1
]}

Ceccarelli, Fulvia ^{[3
]}

Conti, Fabrizio ^{[3
]}

机构：

[1] Sapienza Univ, Dept Translat & Precis Med, Viale Univ 37, I-00185 Rome, Italy

[2] Bambino Gesu Pediat Hosp, IRCCS, Res Unit Clin Immunol & Vaccinol, Rome, Italy

[3] Sapienza Univ Roma, Dipartimento Sci Clin Internist Anestesiolog & Car, Lupus Clin, Rheumatol, Viale Policlin 155, I-00161 Rome, Italy

[4] Univ Pisa, Dept Translat Res & New Technol Med & Surg, Med Sch, Pisa, Italy

[5] Santa Maria Goretti Hosp AUSL Latina, Dept Clin Pathol, Latina, Italy

来源：

IMMUNOLOGY LETTERS | 2025年 / 272卷

关键词：

Systemic lupus erythematosus; Belimumab; T -bet plus B cells; Biomarker; MIXED CRYOGLOBULINEMIA; SELECTION; ABNORMALITIES; EFFICACY; BAFF; BLYS;

D O I：

10.1016/j.imlet.2024.106962

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Systemic lupus erythematosus (SLE) is characterized by B cell dysregulation and expansion of atypical B cells that may correlate with disease manifestations and activity. This study investigated the impact of subcutaneous (sc) Belimumab (BLM) on the peripheral B cell compartment and on the functional properties of CD21low, T-bet+ and CD11c+ atypical B cells, in 21 active SLE patients over a 12-month period. At baseline, active SLE patients displayed reduced unswitched IgM memory B cells and expansion of atypical B cells, compared to healthy donors and to SLE patients in remission. sc BLM therapy promptly restored B cell homeostasis with a reduction of T-bet+ B cells, observed early in patients responsive to therapy. These findings highlight the pathogenic role of T-bet+ B cells in SLE disease and suggest their potential utility as biomarker of clinical response.

引用

页数：10

共 46 条

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