Hepatoprotective Effects and Testicular Toxicity of Centella asiatica L. Aqueous Extract in Diabetic Rats

被引：0
作者：
Aszrin, F. N. [1 ]
Adam, S. H. [2 ]
Mutalib, M. Abdul [1 ]
Hooi, C. T. [3 ]
Gee, H. T. Shirley [4 ]
Shariff, M. H. Mohamad [5 ]
Mokhtar, M. H. [6 ]
机构：
[1] Management & Sci Univ, Sch Grad Studies, Shah Alam, Selangor, Malaysia
[2] Univ Pertahanan Nas Malaysia, Fac Med & Def Hlth, Preclin Dept, Kuala Lumpur 57000, Malaysia
[3] Manipal Univ Coll Malaysia, Fac Med, Dept Microbiol, Melaka, Malaysia
[4] Univ Kebangsaan Malaysia, Ctr Toxicol & Hlth Risk Res CORE, Fac Hlth Sci, Bangi, Selangor, Malaysia
[5] Univ Technol MARA UiTM Pulau Pinang, Fac Hlth Sci, Bertam Campus, Permatang Pauh, Pulau Pinang, Malaysia
[6] Univ Kebangsaan Malaysia, Fac Med, Dept Physiol, Kuala Lumpur, Malaysia
来源：
IIUM MEDICAL JOURNAL MALAYSIA | 2025年 / 24卷 / 01期
关键词：
Centella asiatica; antioxidant; antidiabetic; antifertility; liver; MALE REPRODUCTIVE FUNCTION; IN-VITRO; MELLITUS; ACID; ANTIOXIDANT;
D O I：
10.31436/imjm.v23i04.2501
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
INTRODUCTION: Centella asiatica has been widely studied as an herbal substitute for treating diabetes mellitus (DM). This study aimed to investigate the effects of C. asiatica on the liver and testes in a rat model of type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: Forty adult male Sprague-Dawley rats were induced with diabetes using a single intraperitoneal injection of streptozotocin-nicotinamide (STZ-NA). Three days after induction of diabetes, the rats were treated with either 250 or 500 mg/kg body weight/day of C. asiatica aqueous extract (CAAE) for 48 days. Serum, liver, and testes were collected for analysis. Parameters measured included fasting blood glucose (FBG), body and organ weights, gonadosomatic and hepatosomatic index, testicular steroidogenesis activity (HSD17B3, testosterone levels, sperm count), and liver biochemical markers. Additionally, antioxidant and lipid peroxidation levels, together with sperm count were assessed in the liver and testes respectively. RESULTS: CAAE treatment improved FBG levels and mitigated weight loss in the STZ-NA group. Oxidative stress markers were ameliorated in both organs after CAAE treatment. Liver serum biochemical markers showed improvement, while testicular steroidogenic function declined. Sperm count decreased compared to the STZ-NA group. CONCLUSION: CAAE ameliorates hyperglycaemia and oxidative stress in the liver and testes but may cause testicular dysfunction in DM. In conclusion, the study demonstrated that C. asiatica is able to reverse STZ-NA-induced oxidative stress and hyperglycaemia but exacerbates testicular dysfunction. evaluate our study outcome.
引用
收藏
页码：40 / 48
页数：9
相关论文
共 50 条
  • [1] Institute for Public Health (IPH) NIoH, Ministry of Health Malaysia. Volume I: NCDs – Non- Communicable Diseases: Risk Factors and other Health Problems, (2020)
  • [2] Govender N, Khaliq OP, Moodley J, Naicker T., Insulin resistance in COVID-19 and diabetes, Prim Care Diabetes, 15, 4, pp. 629-634, (2021)
  • [3] Singh A, Kukreti R, Saso L, Kukreti S., Mechanistic Insight into Oxidative Stress-Triggered Signaling Pathways and Type 2 Diabetes, Molecules, 27, 3, (2022)
  • [4] Barkabi-Zanjani S, Ghorbanzadeh V, Aslani M, Ghalibafsabbaghi A, Chodari L., Diabetes mellitus and the impairment of male reproductive function: Possible signaling pathways, Diabetes Metab Syndr, 14, 5, pp. 1307-1314, (2020)
  • [5] Liu L, Shu A, Zhu Y, Chen Y., Cornuside Alleviates Diabetes Mellitus-Induced Testicular Damage by Modulating the Gut Microbiota, Evid Based Complement Alternat Med, 2021, (2021)
  • [6] Mathur S, Mehta DK, Kapoor S, Yadav S., Liver function in type-2 diabetes mellitus patients, Int J Sci Stud, 3, 10, pp. 43-47, (2016)
  • [7] Pearce I, Simo R, Lovestam-Adrian M, Wong DT, Evans M., Association between diabetic eye disease and other complications of diabetes: Implications for care. A systematic review, Diabetes Obes Metab, 21, 3, pp. 467-478, (2019)
  • [8] Unsal V, Dalkiran T, Cicek M, Kolukcu E., The Role of Natural Antioxidants Against Reactive Oxygen Species Produced by Cadmium Toxicity: A Review, Adv Pharm Bull, 10, 2, pp. 184-202, (2020)
  • [9] Sheng X, Che H, Ji Q, Yang F, Lv J, Wang Y, Et al., The relationship between liver enzymes and insulin resistance in type 2 diabetes patients with nonalcoholic fatty liver disease, Hormone and Metabolic Research, 50, pp. 397-402, (2018)
  • [10] Abbasi-Oshaghi E, Khodadadi I, Mirzaei F, Ahmadi M, Tayebinia H, Goodarzi MT., Anethum graveolens L. Alleviates Sperm Damage by Limiting Oxidative Stress and Insulin Resistance in Diabetic Rats, The Open Medicinal Chemistry Journal, 14, 1, (2020)
12345