Fabrication and evaluation of 3D printed PLGA/nHA/GO scaffold for bone tissue engineering

被引：1

作者：

Tong, Ling ^{[1
]}

Shi, Guopeng ^{[1
]}

Liu, Qinghua ^{[1
]}

Qian, Zhiyong ^{[1
]}

Li, Jing ^{[2
]}

Zhang, Kai ^{[3
]}

Zhu, Yong ^{[4
]}

Fang, Yuan ^{[1
]}

Sha, Lirong ^{[1
]}

Bai, Lin ^{[1
]}

Li, Yumo ^{[6
]}

Wang, Xing ^{[5
]}

Ma, Yuan ^{[5
]}

Jirigala, Enhe ^{[1
]}

Wang, Haiyan ^{[1
]}

Li, Xiaohe ^{[1
]}

机构：

[1] Inner Mongolia Med Univ, Sch Basic Med Sci, Dept Human Anat, Hohhot 010010, Inner Mongolia, Peoples R China

[2] Acad Mil Med Sci, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China

[3] Second Hosp Ulanqab City, Dept Orthopaed, Ulanqab 012000, Inner Mongolia, Peoples R China

[4] Inner Mongolia Med Univ, Peking Univ, Inner Mongolia Canc Ctr, Canc Hosp,Affiliated Canc Hosp, Inner Mongolia Campus, Hohhot 010110, Inner Mongolia, Peoples R China

[5] Inner Mongolia Med Univ, Digital Med Ctr, Sch Basic Med Sci, Hohhot 010110, Inner Mongolia, Peoples R China

[6] Inner Mongolia Med Univ, Sch Basic Med Sci, Hohhot 010110, Inner Mongolia, Peoples R China

来源：

SCIENTIFIC REPORTS | 2025年 / 15卷 / 01期

关键词：

3D printing; Scaffold; Bone tissue engineering; Polylactic-co-glycolic acid; Nano-hydroxyapatite; Graphene oxide; BEHAVIOR;

D O I：

10.1038/s41598-025-96099-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The study aimed to fabricate and evaluate a bone tissue engineering scaffold made from a composite of polylactic-co-glycolic acid (PLGA), nano-hydroxyapatite (nHA), and graphene oxide (GO) using low-temperature 3D printing and freeze-drying techniques. The scaffolds were produced with varying compositions: PLGA alone and in combination with nHA and GO. The macro and microstructure, pore size, porosity, mechanical properties, and in vitro biocompatibility were assessed. Bone marrow mesenchymal stem cells (BMSCs) were co-cultured with the scaffolds to evaluate cell adhesion, proliferation, and cytotoxicity. The PLGA/nHA/GO composite scaffolds exhibited optimal pore size and microtopography, enhanced mechanical properties, excellent water absorption, and appropriate degradability. The co-culture with BMSCs demonstrated improved cell adhesion and proliferation, indicating good biocompatibility. The PLGA/nHA/GO composite scaffolds show potential as a bone tissue engineering material due to their favorable properties and biocompatibility, suggesting their suitability for bone defect repair applications.

引用

页数：13

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