Human epicardial adipose tissue-derived factors promote atrial endothelial dysfunction: role of pro-inflammatory cytokines and AT1R/NADPH oxidases/SGLT2 pro-oxidant pathway

被引:0
|
作者
Fakih, W. [1 ]
Alhelou, C. [1 ]
Mroueh, A. [1 ]
Kindo, M. [2 ]
Mommerot, A. [2 ]
Mazzucotelli, J. P. [2 ]
Pieper, M. P. [3 ]
Ohlmann, P. [2 ]
Morel, O. [4 ]
Schini-Kerth, V [1 ]
Jesel, L. [4 ]
机构
[1] Univ Strasbourg, Biomed Res Ctr, UR Translat Cardiovasc Med 3074, Translat Cardiovasc Med, Strasbourg, France
[2] Civil Hosp, Nouvel Hop Civil, Strasbourg, France
[3] Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany
[4] Civil Hosp, Nouvel Hop Civil, Biomed Res Ctr Strasbourg, UR Translat Cardiovasc Med 3074, Strasbourg, France
关键词
D O I
10.1093/eurheartj/ehae666.3728
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:1
相关论文
共 7 条
  • [1] Human calcified aortic valves release procoagulant microparticles inducing endothelial dysfunction and thrombogenicity: Role of the AT1R/NADPH oxidases/SGLT2 pro-oxidant pathway
    Hmadeh, S.
    Trimaille, A.
    Matsushita, K.
    Marchandot, B.
    Zobairi, F.
    Sato, C. H.
    Kindo, M.
    Hoang, T. Minh
    Toti, F.
    Pieper, M.
    Kerth, V. Schini
    Kauffenstein, G.
    Morel, O.
    EUROPEAN HEART JOURNAL, 2023, 44
  • [2] Human Aortic Stenotic Valve-Derived Extracellular Vesicles Induce Endothelial Dysfunction and Thrombogenicity Through AT1R/NADPH Oxidases/SGLT2 Pro-Oxidant Pathway
    Hmadeh, Sandy
    Trimaille, Antonin
    Matsushita, Kensuke
    Marchandot, Benjamin
    Carmona, Adrien
    Zobairi, Fatiha
    Sato, Chisato
    Kindo, Michel
    Hoang, Tam Minh
    Toti, Florence
    Zibara, Kazem
    Hamade, Eva
    Schini-Kerth, Valerie
    Kauffenstein, Gilles
    Morel, Olivier
    JACC-BASIC TO TRANSLATIONAL SCIENCE, 2024, 9 (07): : 845 - 864
  • [3] Increased pro-remodeling and pro-thrombotic responses in the left compared to the right atrial appendage: role of low-grade inflammation and the AT1R/NADPH oxidases/SGLT2 pro-oxidant pathway
    Fakih, W.
    Mroueh, A.
    Alhelou, C.
    Kindo, M.
    Mommerot, A.
    Mazzucotelli, J. P.
    Pieper, M. P.
    Ohlmann, P.
    Morel, O.
    Schini-Kerth, V.
    Jesel, L.
    EUROPEAN HEART JOURNAL, 2023, 44
  • [4] Thrombin Induces SGLT1 and SGLT2 Expression to Promote the AT1R/NADPH Oxidase-Mediated Pro-oxidant Response Inducing Senescence in Atrial Endothelial Cells
    Hasan, Hira
    Park, Sin-Hee
    Belcastro, Eugenia
    Auger, Cyril
    Lee, Hyun-Ho
    Schini-Kerth, Valerie
    DIABETES, 2020, 69
  • [5] FXa promotes endothelial dysfunction and pro-remodeling responses in atrial endothelial cells involving PAR1 and 2 and AT1R/NADPH oxidase/SGLT1/2 pro-oxidant pathways
    Fakih, W.
    Mroueh, A.
    Gong, D.
    Ohlmann, P.
    Morel, O.
    Kerth, V. Schini
    Jesel, L.
    EUROPEAN JOURNAL OF HEART FAILURE, 2022, 24 : 280 - 280
  • [6] SGLT2 expression in the left ventricle of cardiac patients is correlated with low-grade inflammation involving the pro-oxidant AT1R/NADPH oxidases/SGLT2 crosstalk: potential role in heart failure
    Mroueh, A.
    Fakih, W.
    Gong, D. S.
    Auger, C.
    Pieper, M. P.
    Morel, O.
    Mazzucotelli, J. P.
    Schini-Kerth, V.
    EUROPEAN HEART JOURNAL, 2023, 44
  • [7] Takotsubo syndrome induced oxidative stress and endothelial dysfunction in left ventricle of rat model: association with NADPH oxidases/SGLT2 pro- oxidant pathway
    Tatarcheh, T.
    Amissi, S.
    Matsushita, K.
    Mroueh, A.
    Muzammel, H.
    Trimaille, A.
    Gong, D.
    Fakih, W.
    Faucher, L.
    Granier, A.
    Pieper, M. P.
    Schini-Kerth, V
    Morel, O.
    EUROPEAN HEART JOURNAL, 2024, 45