Comparative cellular toxicity between silver and poly (lactic-co-glycolic acid) nanoparticles

被引：0

作者：

Chaves, Marlos de Medeiros ^{[1
]}

Moura, Afonso Luiz Dantas ^{[2
]}

de Sousa, Jeanlex Soares ^{[2
]}

Ferreira, Odair Pastor ^{[3
]}

Saraiva, Karina Lidiane Alcantara ^{[4
]}

Miguel, Emilio de Castro ^{[5
,6
]}

Savino, Wilson ^{[7
]}

Nicolete, Roberto ^{[1
]}

机构：

[1] Fundacao Oswaldo Cruz, Fiocruz, Fiocruz Ceara, Eusebio, Brazil

[2] Fed Univ Ceara UFC, Dept Phys, Fortaleza, Brazil

[3] State Univ Londrina UEL, Dept Chem, Londrina, Brazil

[4] Fundacao Oswaldo Cruz, Inst Aggeu Magalhaes, Recife, Brazil

[5] Fed Univ Ceara UFC, Dept Met Engn & Mat DEMM, Fortaleza, Brazil

[6] Fed Univ Ceara UFC, Analyt Ctr, Fortaleza, Brazil

[7] Fundacao Oswaldo Cruz, Oswaldo Cruz Inst IOC, Fiocruz, Rio De Janeiro, Brazil

来源：

TOXIN REVIEWS | 2025年 / 44卷 / 02期

关键词：

Silver nanoparticles; PLGA nanoparticles; Caco-2; cells; in vitro cytotoxicity; cellular integrity; cellular elasticity; PLGA-BASED NANOPARTICLES; EXTRACELLULAR VESICLES; INTESTINAL BARRIER; VISCOELASTICITY; PROLIFERATION; EXOSOMES; RHEOLOGY; DELIVERY; MODELS; IMPACT;

D O I：

10.1080/15569543.2024.2417894

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Nanoparticles composed of poly (lactic-co-glycolic acid) (PLGANPs) and silver (AgNPs) are relevant in the context of their interactions with biological systems. This study aims to evaluate the potential in vitro cytotoxic effects of both PLGANPs and AgNPs on a human colorectal adenocarcinoma cell line (Caco-2). The impact of nanoparticles on cellular toxicity, morphology, microvilli density and viscoelasticity were assessed. After 48 hours incubation with PLGANPs, cells exhibited a modest proliferation compared to the control (6 to14%), low reactive nitrogen species (RNS) production (2 mu M) and higher microvilli densities. In contrast, AgNPs displayed significant toxicity (LC50 = 3.76 mu g/mL) and elevated RNS production.

引用

页码：196 / 210

页数：15

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