Is there an association between inflammatory biomarkers and organ space surgical site infection after emergency laparotomy in massively transfused trauma patients?

被引：0

作者：

Ugarte, Stephanie Martinez ^{[1
,2
]}

Fajemisin, Mokunfayo O. ^{[1
,2
]}

Guy-Frank, Chelsea J. ^{[2
]}

Klugh, James M. ^{[2
]}

Zhang, Xu ^{[3
]}

Fox, Erin E. ^{[1
,2
]}

Wade, Charles E. ^{[1
,2
]}

Mankiewicz, Kimberly A. ^{[1
]}

Kao, Lillian S. ^{[2
]}

机构：

[1] Univ Texas Hlth Sci Ctr Houston, Ctr Translat Injury Res, Dept Surg, McGovern Med Sch, Houston, TX USA

[2] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Div Acute Care Surg, McGovern Med Sch, Houston, TX USA

[3] Univ Texas Hlth Sci Ctr Houston, Ctr Clin & Translat Sci, McGovern Med Sch, Houston, TX USA

来源：

AMERICAN JOURNAL OF SURGERY | 2025年 / 244卷

基金：

美国国家卫生研究院;

关键词：

OUTCOMES; PLASMA;

D O I：

10.1016/j.amjsurg.2024.116106

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: The relationship between inflammatory biomarkers (IB) and organ space surgical site infections (OS-SSIs) after emergency laparotomy (EL) is poorly understood. Methods: Retrospective, single-center analysis of patients in the Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR) trial who underwent EL and survived 48 h after admission was performed. IB levels of IL-6, IL-8, G-CSF, MCP-1, neutrophil to lymphocyte ratio, and platelet to lymphocyte ratio were analyzed. IB and OS-SSIs association was evaluated using the Wilcoxon rank sum test. Results: Of 74 eligible patients, 80% were male, 69% sustained blunt trauma, the injury severity score was 31 (24-41), and 22% developed OS-SSIs. Levels of IL-6 (12, 24 h), IL-8 (2, 12, 24, 72 h), and MCP-1 (24 h) were higher in OS-SSI patients (P < 0.05). Conclusions: IL-6, IL-8, and MCP-1 levels were associated with OS-SSIs in PROPPR patients who underwent EL. The IB may help to predict high-risk patients for OS-SSIs.

引用

页数：5

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