Abietane Diterpenoids from the Rhizomes of Kaempferia roscoeana and Their Anti-Inflammatory Activities

被引：1

作者：

Chokchaisiri, Ratchanaporn ^{[1
]}

Kaisoda, Apinya ^{[1
]}

Cheenpracha, Sarot ^{[1
]}

Ganranoo, Lucksagoon ^{[1
]}

Bureekaew, Sareeya ^{[2
]}

Thepmalee, Chutamas ^{[3
]}

Suksamrarn, Apichart ^{[4
,5
]}

机构：

[1] Univ Phayao, Sch Sci, Dept Chem, Muang 56000, Phayao, Thailand

[2] Vidyasirimedhi Inst Sci & Technol VISTEC, Dept Energy Sci & Engn, Rayong 21210, Thailand

[3] Univ Phayao, Sch Med Sci, Div Biochem, Phayao 56000, Thailand

[4] Ramkhamhang Univ, Fac Sci, Dept Chem, Bangkok 10240, Thailand

[5] Ramkhamhang Univ, Ctr Excellence Innovat Chem, Fac Sci, Bangkok 10240, Thailand

来源：

JOURNAL OF NATURAL PRODUCTS | 2024年 / 87卷 / 12期

关键词：

ANTIOXIDANT;

D O I：

10.1021/acs.jnatprod.4c01127

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six new abietane diterpenes, roscoeananes A-F (1-6), along with two known compounds (7-8) were isolated from the rhizomes of Kaempferia roscoeana. The structures of all compounds were elucidated by analysis of spectroscopic data, and the absolute configurations were assigned by a comparison of the theoretical and experimental electronic circular dichroism (ECD) spectra and a comparison with literature values. The unreported compound 5 is an ether-linked dimer of roscoeanane B (2). Most of the isolated compounds were tested for their nitric oxide inhibitory effects in lipopolysaccharide-activated RAW264.7 cells. Among them, roscoeanane A (1) was found to reduce NO levels in murine macrophage cells with an IC50 value of 3.58 +/- 0.95 mu M and exhibited low cytotoxicity (IC50 > 50 mu M).

引用

页码：2847 / 2854

页数：8

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