Antimicrobial Peptides From Different Sources: Isolation, Purification, and Characterization to Potential Applications

被引：2
|
作者：
Ahmed, Shadi Ali Hassen [1 ,2 ]
Saif, Bassam [3 ,4 ]
Qian, Linghui [1 ,2 ]
机构：
[1] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou Inst Innovat Med, Hangzhou, Peoples R China
[2] Zhejiang Univ, Inst Drug Metab & Pharmaceut Anal, Hangzhou, Peoples R China
[3] Shaanxi Normal Univ, Minist Educ, Sch Chem & Chem Engn, Key Lab Appl Surface & Colloid Chem, Xian, Peoples R China
[4] Ibb Univ, Fac Sci, Chem Dept, Ibb, Yemen
来源：
JOURNAL OF SEPARATION SCIENCE | 2024年 / 47卷 / 23期
基金：
中国国家自然科学基金;
关键词：
antimicrobial peptides; characterizations; different sources; isolation; purification; AMINO-ACID-SEQUENCE; HOST-DEFENSE PEPTIDES; CLASS IIA BACTERIOCIN; ANTIBACTERIAL PEPTIDE; CDNA CLONING; INHIBITORY-ACTIVITIES; IMPATIENS-BALSAMINA; ANTICANCER ACTIVITY; ANTIFUNGAL PEPTIDE; MOLECULAR-CLONING;
D O I：
10.1002/jssc.70043
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Antimicrobial peptides (AMPs) are excellent promising candidates for biomedical applications owing to their structural properties, high biocompatibility, good biodegradability, and functional diversity. Unlike conventional antibiotics, AMPs have been shown to have broad-spectrum antimicrobial activity toward Gram-positive/negative bacteria, as well as antifungal and antiviral activity. These peptides have also been found to be cytotoxic to sperm and cancer cells. A range of AMPs has been isolated from various organisms, such as bacteria, fungi, plants, and animals. This review summarizes the latest studies on AMPs, covering their isolation, purification, and characterization as well as their potential biomedical applications and beyond.
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页数：36
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