Antiarthritic effects of polyunsaturated fatty acid-rich supplementation combined with selective soluble epoxide hydrolase inhibitors in a collagen-induced arthritis mouse model

被引：2

作者：

Yoshida, Akiko ^{[1
,2
]}

Murakami, Kosaku ^{[2
]}

Tsukamoto, Hirotake ^{[2
]}

Hotta, Yunhong ^{[2
]}

Nakayama, Yoichi ^{[1
]}

Saito, Rintaro ^{[1
]}

Shirakashi, Mirei ^{[1
]}

Tsuji, Hideaki ^{[1
]}

Hiwa, Ryosuke ^{[1
]}

Akizuki, Shuji ^{[1
]}

Nakashima, Ran ^{[1
]}

Yoshifuji, Hajime ^{[1
]}

Onishi, Akira ^{[3
]}

Tanaka, Masao ^{[3
]}

Mimori, Tsuneyo ^{[1
,4
]}

Morinobu, Akio ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Rheumatol & Clin Immunol, Kyoto, Japan

[2] Kyoto Univ, Ctr Canc Immunotherapy & Immunobiol, Grad Sch Med, Div Clin Immunol & Canc Immunotherapy, Yoshida Konoe Cho,Sakyo Ku, Kyoto 6068501, Japan

[3] Kyoto Univ, Grad Sch Med, Dept Adv Med Rheumat Dis, Kyoto, Japan

[4] Matsuno Clin Rheumat Dis, Kyoto, Japan

来源：

MODERN RHEUMATOLOGY | 2025年 / 35卷 / 04期

关键词：

Collagen-induced arthritis; gut microbiota; polyunsaturated fatty acids; rheumatoid arthritis; soluble epoxide hydrolase inhibitors; RHEUMATOID-ARTHRITIS; PHARMACOLOGICAL INHIBITION;

D O I：

10.1093/mr/roaf019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives Polyunsaturated fatty acids (PUFAs) are healthy fats that contain a double carbon bond. They are made up of omega (omega)-3 and omega-6 PUFAs, where omega-3 PUFAs exhibit beneficial effects, such as the suppression of cardiovascular events and the improvement of abnormal lipid metabolism. However, their effects on rheumatoid arthritis (RA) are unclear. Epoxy fatty acids, which are intermediate metabolites of omega-6 and omega-3 PUFAs, are formed through the action of cytochrome P and possess anti-inflammatory properties. However, they are quickly converted into their inactive forms by soluble epoxide hydrolase.Methods The protective effects of omega-3 and omega-6 PUFAs on arthritic symptoms with or without soluble epoxide hydrolase inhibitors (sEHis) were investigated in a collagen-induced arthritis mouse model.Results The group treated with a combination of omega-3 PUFAs and sEHi showed a marked inhibition of arthritis compared to the other groups. Analysis of the faecal flora before the onset of arthritis showed an inverse correlation between the arthritis score and the relative abundance of Lactococcus, suggesting that changes in the intestinal flora in the preclinical stage may influence the onset of arthritis.Conclusions This study highlights the potential of omega-3 PUFAs combined with sEHi as the novel protective effect for RA.

引用

页码：665 / 676

页数：12

共 51 条

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