Animal Models for Studying Developmental Origins of Cardiovascular-Kidney-Metabolic Syndrome

被引：1

作者：

Tain, You-Lin ^{[1
,2
,3
]}

Lin, Ying-Jui ^{[4
,5
,6
,7
,8
]}

Hsu, Chien-Ning ^{[9
,10
,11
]}

机构：

[1] Kaohsiung Chang Gung Mem Hosp, Div Pediat Nephrol, Kaohsiung 833, Taiwan

[2] Chang Gung Univ, Coll Med, Taoyuan 333, Taiwan

[3] Kaohsiung Municipal Tatung Hosp, Dept Pediat, Kaohsiung 801, Taiwan

[4] Kaohsiung Chang Gung Mem Hosp, Div Crit Care, Dept Pediat, Kaohsiung 833, Taiwan

[5] Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan

[6] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Div Cardiol, Kaohsiung 833, Taiwan

[7] Kaohsiung Chang Gung Mem Hosp, Dept Resp Therapy, Kaohsiung 833, Taiwan

[8] Cheng Shiu Univ, Dept Early Childhood Care & Educ, Kaohsiung 833, Taiwan

[9] Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan

[10] Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan

[11] Kaohsiung Municipal Tatung Hosp, Dept Pharm, Kaohsiung 801, Taiwan

来源：

BIOMEDICINES | 2025年 / 13卷 / 02期

关键词：

animal model; developmental origins of health and disease (DOHaD); oxidative stress; microbiota; cardiovascular disease; metabolic syndrome; renin-angiotensin system; kidney disease; nitric oxide; epigenetic regulation; RENIN-ANGIOTENSIN SYSTEM; MATERNAL NICOTINE EXPOSURE; INCREASES BLOOD-PRESSURE; REDUCES NEPHRON NUMBER; IN-UTERO EXPOSURE; LOW-PROTEIN DIET; HIGH-FAT-DIETS; OXIDATIVE STRESS; PRENATAL EXPOSURE; INSULIN SENSITIVITY;

D O I：

10.3390/biomedicines13020452

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cardiovascular-kidney-metabolic syndrome (CKMS) has become a significant global health challenge. Since CKMS often originates early in life, as outlined by the developmental origins of health and disease (DOHaD) concept, prevention is a more effective strategy than treatment. Various animal models, classified by environmental exposures or mechanisms, are used to explore the developmental origins of CKMS. However, no single model can fully replicate all aspects of CKMS or its clinical stages, limiting the advancement of preventive and therapeutic strategies. This review aims to assist researchers by comparing the strengths and limitations of common animal models used in CKMS programming studies and highlighting key considerations for selecting suitable models.

引用

页数：21

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