Size Effects of Nanoenabled Agrochemicals in Sustainable Crop Production: Advances, Challenges, and Perspectives

Nanoenabled agrochemicals mainly including nanopesticides and nanofertilizers based on nanotechnology play a crucial role in plant protection and food security. These agrochemicals exhibit high dose delivery efficiency and biological activity due to their unique nanoscale properties. However, nanoscale properties can also be a double-edged sword, posing potential risks to both humans and the environment. As nanoenabled agrochemicals become more widely used, it is essential to have an objective and comprehensive discussion of the size effects of these agrochemicals. In this paper, we reviewed the research progress on the size effects of nanoenabled agrochemicals in terms of dose delivery, biological activity, and nontarget safety. We investigated the complex factors affecting size effects and sought to draw insights from research in biomedicine, engineering, food, and other relevant fields. Based on the literatures review, it could be concluded that the smaller the better is not always the case. We further outlooked the development prospects of studying the size effects of nanoenabled agrochemicals, emphasizing the necessity for thorough and in-depth research while critically identifying key issues that need to be addressed. In conclusion, a proper comprehension of the size effects of nanoenabled agrochemicals bridges the gap between the scientific community and industry, bolstering the role in advancing sustainable agriculture. © 2024 American Chemical Society.