Bridging brain insulin resistance to Alzheimer's pathogenesis

被引：7

作者：

Chen, Wenqiang ^{[1
,2
]}

Johansen, Valdemar Brimnes Ingemann ^{[3
]}

Legido-Quigley, Cristina ^{[2
,4
]}

机构：

[1] Harvard Med Sch, Joslin Diabet Ctr, Boston, MA 02215 USA

[2] Steno Diabet Ctr Copenhagen, DK-2730 Herlev, Denmark

[3] Univ Copenhagen, Novo Nord Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, DK-2100 Copenhagen, Denmark

[4] Kings Coll London, Inst Pharmaceut Sci, London SE5 9RX, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2024年 / 49卷 / 11期

关键词：

STRESS;

D O I：

10.1016/j.tibs.2024.09.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Emerging evidence links type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), with brain insulin resistance (BIR) as a key factor. In a recent study, Lanzillotta et al. reveal that reduced biliverdin reductase-A (BVR-A) impairs glycogen synthase kinase 3(3 (GSK3(3) phosphorylation, causing mitochondrial dysfunction and exacerbating brain insulin resistance in the progression of both T2DM and AD.

引用

页码：939 / 941

页数：3

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