Anti-Inflammatory Secoiridoids from the Medicinal Herb Gentianopsis barbata

被引：1

作者：

Liu, Huan ^{[1
,2
]}

Cheng, Hui-Zhen ^{[1
,2
]}

Qi, Xiao-Yu ^{[1
,2
]}

Fan, Yu-Zhou ^{[1
,2
]}

Yuan, Zhong-Zhu ^{[1
,2
]}

Xu, Yuan-Liang ^{[1
,2
]}

Liu, Yan ^{[1
,2
]}

Guo, Kai ^{[1
,2
]}

Li, Sheng-Hong ^{[1
,2
,3
,4
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China

[2] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China

[3] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Nat Med, Kunming 650201, Peoples R China

[4] Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2025年 / 22卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Anti-inflammatory activity; Gentianopsins A-E; Gentianopsis barbata; Gentianaceae; Secoiridoids; IRIDOIDS;

D O I：

10.1002/cbdv.202402653

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five new secoiridoids, gentianopsins A-E (1-5), along with two known analogues (6 and 7) were isolated from the whole plants of the medicinal herb Gentianopsis barbata. Their structures were elucidated by a comparison of extensive spectroscopic analysis (1D and 2D NMR, and HRMS) and quantum chemical calculations. Gentianopsins A (1) and B (2) represented two unusual skeletons of trihomo-secoiridoids. Anti-inflammatory activity of these isolates was evaluated via suppressing the secretion of cytokines TNF-alpha and IL-6 in LPS-induced macrophages RAW264.7. Significant inhibitory activity was observed for compounds 3 and 7 on IL-6 secretion with IC50 values of 10.22 and 13.30 mu M, respectively.

引用

页数：6

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