Evaluation of neutrophil-lymphocyte, platelet-lymphocyte ratio changes in patients with acute and chronic urticaria

Study objective. - This study aimed to evaluate the changes in inflammatory markers, specifically neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), in pediatric patients with acute and chronic urticaria. The objective was to compare these inflammatory indices between patients with acute urticaria, chronic urticaria, and healthy controls to determine whether they can be used as potential biomarkers for the evaluation of urticaria. Patients and methods. - The study included 200 participants: 100 with acute urticaria, 50 with chronic urticaria, and 50 healthy controls, all aged 0-18 years. Blood samples were taken to calculate NLR, PLR, systemic immune-inflammation index (SII), and other related indices. Specific allergen sensitivities were also evaluated using specific IgE tests and skin prick tests. Results. - The study found significant differences in NLR, PLR, and SII between the acute and chronic urticaria groups and the control group. NLR and PLR were significantly higher in the chronic urticaria group, suggesting ongoing inflammation. No significant difference was found in monocyte, platelet, eosinophil, and basophil counts. Conclusion. - The findings suggest that NLR, PLR, and SII could be potential biomarkers for assessing the inflammatory response in urticaria, particularly in differentiating between acute and chronic forms. However, further research is needed to confirm the clinical utility of these markers for routine evaluation in urticaria patients. (c) 2025 Socie<acute accent>te<acute accent> franc,aise d'allergologie. Published by Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.