Recent advancements of pyrimidine chemistry thriving deeper into drug discovery

被引:0
作者
Martis, Glanish Jude [1 ]
Sneha, O. [1 ]
Bhat, D. Rajkumar [1 ]
Mugali, Praveen S. [1 ]
机构
[1] Alvas Coll Autonomous, Dept PG Studies Chem, Moodubidire, Karnataka, India
关键词
Pyrimidine; synthetic strategy; biological activity; drug discovery; medicinal chemistry; PYRIMIDINE-5-CARBONITRILE DERIVATIVES; BIOLOGICAL EVALUATION; IN-SILICO; DESIGN; INHIBITORS; 5-LIPOXYGENASE; EFFICACY; REGIMEN;
D O I
10.1080/00397911.2025.2487080
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Pyrimidine-containing organic compounds have been widely studied and are highly important. With this intent, a genuine attempt has been made to reflect the various synthetic developments and biological perspectives of pyrimidine-containing analogues leading to drug design and discovery. The synthetic strategies give the in-depth route of generating pyrimidines. The biology includes antiviral, antioxidant, anti-inflammatory, and anticancer, activities. By going in depth with all the studies made by various researchers, the scope of pyrimidine is vast. The extensive properties exhibited by various compounds reveal the ability of pyrimidines to act as potent drugs in future. Most of the compounds showed better performance than the standard drugs available. Therefore, the need for reviewing all the recent advances in pyrimidine-related chemistry was necessary and it will aid to boost the research both in academic and pharma sector.
引用
收藏
页码:863 / 891
页数:29
相关论文
共 94 条
[1]   Synthesis and anticancer activity of some pyrido[2,3-d]pyrimidine derivatives as apoptosis inducers and cyclin-dependent kinase inhibitors [J].
Abbas, Safinaz E-S ;
George, Riham F. ;
Samir, Eman M. ;
Aref, Mostafa M. A. ;
Abdel-Aziz, Hatem A. .
FUTURE MEDICINAL CHEMISTRY, 2019, 11 (18) :2395-2414
[2]   Real-world efficacy and safety outcomes of imatinib treatment in patients with chronic myeloid leukemia: An Australian experience [J].
Adattini, Josephine A. ;
Gross, Annette S. ;
Doo, Nicole Wong ;
McLachlan, Andrew J. .
PHARMACOLOGY RESEARCH & PERSPECTIVES, 2022, 10 (05)
[3]  
Aher Sanket N., 2024, Biosciences Biotechnology Research Asia, V21, P741, DOI 10.13005/bbra/3261
[4]   Pyrimidine-5-carbonitrile derivatives as sprout for CQDs proveniences: Antitumor and anti-inflammatory potentiality [J].
Ahmed, Hanan B. ;
Mikhail, Mary M. ;
Abdallah, Amira E. M. ;
El-Shahat, Mahmoud ;
Emam, Hossam E. .
BIOORGANIC CHEMISTRY, 2023, 141
[5]   Heterocyclic pyrimidine derivatives as promising antibacterial agents [J].
Ahmed, Kainat ;
Choudhary, M. Iqbal ;
Saleem, Rahman Shah Zaib .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 259
[6]   New Indazol-Pyrimidine-Based Derivatives as Selective Anticancer Agents: Design, Synthesis, and In Silico Studies [J].
Al-Tuwaijri, Hanaa M. ;
Al-Abdullah, Ebtehal S. ;
El-Rashedy, Ahmed A. ;
Ansari, Siddique Akber ;
Almomen, Aliyah ;
Alshibl, Hanan M. ;
Haiba, Mogedda E. ;
Alkahtani, Hamad M. .
MOLECULES, 2023, 28 (09)
[7]   Synthesis and Molecular Docking Study of Novel Pyrimidine Derivatives against COVID-19 [J].
Alamshany, Zahra M. ;
Khattab, Reham R. ;
Hassan, Nasser A. ;
El-Sayed, Ahmed A. ;
Tantawy, Mohamed A. ;
Mostafa, Ahmed ;
Hassan, Allam A. .
MOLECULES, 2023, 28 (02)
[8]   Synthesis, antimicrobial and antioxidant activities of some new pyrazolo[1,5-a]pyrimidine and imidazo[1,2-b]pyrazole derivatives based isoxazole [J].
Alamshany, Zahra M. M. ;
Tashkandi, Nada Y. Y. ;
Othman, Ismail M. M. ;
Ishak, Esam A. A. ;
Gad-Elkareem, Mohamed A. M. .
SYNTHETIC COMMUNICATIONS, 2023, 53 (17) :1451-1467
[9]   Synthesis, characterization, docking study and biological evaluation of new chalcone, pyrazoline, and pyrimidine derivatives as potent antimalarial compounds [J].
Alidmat, Mohammad Murwih ;
Khairuddean, Melati ;
Norman, Naziera Mohammad ;
Asri, Anis Nasihah Mohamed ;
Suhaimi, Mohd Hisyam Mohd ;
Sharma, Garima .
ARABIAN JOURNAL OF CHEMISTRY, 2021, 14 (09)
[10]   Design, synthesis, characterization, and antimicrobial evaluation of the novel 2-heteroarylchromeno[2,3-d]pyrimidines [J].
Alshaye, Najla A. ;
Ibrahim, Magdy A. .
SYNTHETIC COMMUNICATIONS, 2023, 53 (10) :744-754