Harnessing bacterial antimicrobial peptides: a comprehensive review on properties, mechanisms, applications, and challenges in combating antimicrobial resistance

被引：0
|
作者：
Erriah, Pirasannah [1 ]
Puan, Sheau Ling [1 ]
Yahaya, Normi Mohd [2 ]
Wan Ahmad Kamil, Wan Nur Ismah [3 ]
Amin Nordin, Syafinaz [4 ]
Muhamad, Azira [5 ]
Sabri, Suriana [1 ,3 ]
机构：
[1] Univ Putra Malaysia UPM, Fac Biotechnol & Biomol Sci, Enzyme & Microbial Technol Res Ctr, Serdang 43400, Selangor, Malaysia
[2] Univ Putra Malaysia UPM, Fac Biotechnol & Biomol Sci, Dept Cell & Mol Biol, Serdang 43400, Selangor, Malaysia
[3] Univ Putra Malaysia UPM, Fac Biotechnol & Biomol Sci, Dept Microbiol, Serdang 43400, Selangor, Malaysia
[4] Univ Putra Malaysia UPM, Fac Med & Hlth Sci, Dept Med Microbiol & Parasitol, Serdang 43400, Selangor, Malaysia
[5] Natl Inst Biotechnol Malaysia, Serdang 43400, Selangor, Malaysia
来源：
JOURNAL OF APPLIED MICROBIOLOGY | 2025年 / 136卷 / 03期
关键词：
antimicrobial resistance; emergence of resistance; bacterial-derived antimicrobial peptides; bioactive agents; mechanisms of action; diverse applications; CLASS IIA BACTERIOCIN; ANTIBACTERIAL PEPTIDES; PHYSICOCHEMICAL PROPERTIES; LISTERIA-MONOCYTOGENES; ESCHERICHIA-COLI; MODEL MEMBRANES; POLYMYXIN-B; IN-VITRO; LIPID II; EXPRESSION;
D O I：
10.1093/jambio/lxae290
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Antimicrobial resistance (AMR) is a significant global health concern due to the persistence of pathogens and the emergence of resistance in bacterial infections. Bacterial-derived antimicrobial peptides (BAMPs) have emerged as a promising strategy to combat these challenges. Known for their diversity and multifaceted nature, BAMPs are notable bioactive agents that exhibit potent antimicrobial activities against various pathogens. This review explores the intricate properties and underlying mechanisms of BAMPs, emphasizing their diverse applications in addressing AMR. Additionally, the review investigates the mechanisms, analyses the challenges in utilizing BAMPs effectively, and examines their potential applications and associated deployment challenges providing comprehensive insights into how BAMPs can be harnessed to combat AMR across different domains. The significance of this review lies in highlighting the potential of BAMPs as transformative agents in combating AMR, offering sustainable and eco-friendly solutions to this pressing global health challenge.
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页数：23
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