Mismatch repair deficiency and its relationship with histopathological features in gastric cancer patients

被引：0

作者：

Nguyen, Thi Hong Chuyen ^{[1
]}

Nguyen, Tran Bao Song ^{[2
]}

Nguyen, Thanh Phuc ^{[3
]}

Ha, Thi Minh Thi ^{[4
]}

Pham, Nguyen Cuong ^{[5
]}

Nguyen, Thi Thu Giang ^{[6
]}

Phan, Minh Tri ^{[1
]}

Le, Thanh Huy ^{[1
]}

Ha, Thanh Thanh ^{[1
]}

Nguyen, Tran Thuc Huan ^{[1
]}

Dang, Cong Thuan ^{[2
]}

机构：

[1] Hue Univ, Univ Med & Pharm, Dept Oncol, Hue, Vietnam

[2] Hue Univ, Univ Med & Pharm, Dept Histol Embryol Pathol & Forens Med, 06 Ngo Quyen St, Hue 530000, Vietnam

[3] Hue Univ, Univ Med & Pharm, Dept Anat Surg Training, Hue, Vietnam

[4] Hue Univ, Univ Med & Pharm, Dept Med Genet, Hue, Vietnam

[5] Hue Cent Hosp, Dept Pathol, Hue, Vietnam

[6] Vinmec Cent Pk Int Hosp, Oncol Ctr, Ho Chi Minh City, Vietnam

来源：

NAGOYA JOURNAL OF MEDICAL SCIENCE | 2025年 / 87卷 / 01期

关键词：

gastric cancer; microsatellite instability; mismatch repair deficiency; histopathological features; immunohistochemical; MICROSATELLITE INSTABILITY; PROGNOSTIC VALUE; CHEMOTHERAPY;

D O I：

10.18999/nagjms.87.1.93

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Gastric cancer is a common malignancy disease with a poor prognosis. Deficient mismatch repair is a prognostic and predictive marker of response to systemic therapies. However, deficient mismatch repair frequency and the relationship between this status and microscopic characteristics are inconsistent across nations. We aimed to determine the rate of deficient mismatch repair and its association with histopathological features in gastric cancer patients. A cross-sectional study was conducted on 226 gastric cancer patients January 2024. Mismatch repair protein expression was evaluated using immunohistochemical staining, and any absence of mismatch repair proteins was regarded as deficient mismatch repair. The deficient mismatch repair rate was 12.8%. Deficient mismatch repair appeared to be more frequent in the intestinal subtype of Lauren classification odds ratio (OR) = 4.767 (95% confidence interval [CI], 1.086-20.921; p = 0.039), tubular/papillary adenocarcinoma (OR = 5.25; 95% CI, 1.185-23.251; p = 0.029), mucinous adenocarcinoma (OR = 6.19; 95% CI, 1.113-34.445; p = 0.037), and differentiated type (OR = 3.24; 95% CI, 1.324-7.931; p = 0.01). No statistically significant association was detected with histopathological features according to the Tumor Location-Modified Lauren classification and mucinous secreting morphology. Deficient mismatch repair status was unusual in gastric cancer. The degree of cell differentiation and microscopic characteristics based on the World Health Organization and Lauren classification could all impact the predictive power for microsatellite-instable status.

引用

页码：93 / 104

页数：12

共 36 条

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