Understanding antimicrobial pharmacokinetics in critically ill patients to optimize antimicrobial therapy: A narrative review

被引：3
作者：
Roger, Claire [1 ,2 ]
机构：
[1] Nimes Caremeau Univ Hosp, Dept Anesthesiol & Intens Care Pain & Emergency Me, Pl Prof Robert Debre, F-30029 Nimes 9, France
[2] Montpellier Univ, Fac Med, UR IMAGINE Initial Management & Prevent OrGan Fail, Montpellier, France
来源：
JOURNAL OF INTENSIVE MEDICINE | 2024年 / 4卷 / 03期
关键词：
Pharmacokinetics/pharmacodynamics; ICU; Antibiotics; Dose optimization; TDM; AUGMENTED RENAL CLEARANCE; CARE-UNIT PATIENTS; CEFEPIME PLASMA-CONCENTRATIONS; FEBRILE NEUTROPENIC PATIENTS; BETA-LACTAM ANTIBIOTICS; TARGET SITE PENETRATION; CONTINUOUS-INFUSION; POPULATION PHARMACOKINETICS; COLISTIN METHANESULFONATE; INTRAVENOUS FOSFOMYCIN;
D O I：
10.1016/j.jointm.2023.12.007
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Effective treatment of sepsis not only demands prompt administration of appropriate antimicrobials but also requires precise dosing to enhance the likelihood of patient survival. Adequate dosing refers to the administration of doses that yield therapeutic drug concentrations at the infection site. This ensures a favorable clinical and microbiological response while avoiding antibiotic-related toxicity. Therapeutic drug monitoring (TDM) is the recommended approach for attaining these goals. However, TDM is not universally available in all intensive care units (ICUs) and for all antimicrobial agents. In the absence of TDM, healthcare practitioners need to rely on several factors to make informed dosing decisions. These include the patient's clinical condition, causative pathogen, impact of organ dysfunction (requiring extracorporeal therapies), and physicochemical properties of the antimicrobials. In this context, the pharmacokinetics of antimicrobials vary considerably between different critically ill patients and within the same patient over the course of ICU stay. This variability underscores the need for individualized dosing. This review aimed to describe the main pathophysiological changes observed in critically ill patients and their impact on antimicrobial drug dosing decisions. It also aimed to provide essential practical recommendations that may aid clinicians in optimizing antimicrobial therapy among critically ill patients.
引用
收藏
页码：287 / 298
页数：12
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共 128 条
  • [11] Udy A.A., Varghese J.M., Altukroni M., Briscoe S., McWhinney B.C., Ungerer J.P., Et al., Subtherapeutic initial beta-lactam concentrations in select critically ill patients: association between augmented renal clearance and low trough drug concentrations, Chest, 142, 1, pp. 30-39, (2012)
  • [12] Carrie C., Bentejac M., Cottenceau V., Masson F., Petit L., Cochard J.F., Et al., Association between augmented renal clearance and clinical failure of antibiotic treatment in brain-injured patients with ventilator-acquired pneumonia: a preliminary study, Anaesth Crit Care Pain Med, 37, 1, pp. 35-41, (2018)
  • [13] Carrie C., Petit L., d'Houdain N., Sauvage N., Cottenceau V., Lafitte M., Et al., Association between augmented renal clearance, antibiotic exposure and clinical outcome in critically ill septic patients receiving high doses of beta-lactams administered by continuous infusion: a prospective observational study, Int J Antimicrob Agents, 51, 3, pp. 443-449, (2018)
  • [14] Jacobs A., Taccone F.S., Roberts J.A., Jacobs F., Cotton F., Wolff F., Et al., Beta-lactam dosage regimens in septic patients with augmented renal clearance, Antimicrob Agents Chemother, 62, 9, pp. e02517-e02534, (2018)
  • [15] Carrie C., Chadefaux G., Sauvage N., de Courson H., Petit L., Nouette-Gaulain K., Et al., Increased beta-lactams dosing regimens improve clinical outcome in critically ill patients with augmented renal clearance treated for a first episode of hospital or ventilator-acquired pneumonia: a before and after study, Crit Care, 23, 1, (2019)
  • [16] Baptista J.P., Neves M., Rodrigues L., Teixeira L., Pinho J., Pimentel J., Accuracy of the estimation of glomerular filtration rate within a population of critically ill patients, J Nephrol, 27, 4, pp. 403-410, (2014)
  • [17] Baptista J.P., Udy A.A., Sousa E., Pimentel J., Wang L., Roberts J.A., Et al., A comparison of estimates of glomerular filtration in critically ill patients with augmented renal clearance, Crit Care, 15, 3, (2011)
  • [18] Gijsen M., Wilmer A., Meyfroidt G., Wauters J., Spriet I., Can augmented renal clearance be detected using estimators of glomerular filtration rate?, Crit Care, 24, 1, (2020)
  • [19] Mikami R., Hayakawa M., Imai S., Sugawara M., Takekuma Y., Onset timing and duration of augmented renal clearance in a mixed intensive care unit, J Intensive Care, 11, 1, (2023)
  • [20] Hoste E.A., Bagshaw S.M., Bellomo R., Cely C.M., Colman R., Cruz D.N., Et al., Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study, Intensive Care Med, 41, 8, pp. 1411-1423, (2015)
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