Incorporating microbial cell-free DNA testing into healthcare-associated invasive fungal infection surveillance: benefits and challenges

被引：0

作者：

Uslan, Daniel Z. ^{[1
,2
]}

Kaur, Ishminder ^{[3
]}

Garner, Omai B. ^{[4
]}

Yang, Shangxin ^{[4
]}

机构：

[1] UCLA, Dept Med, Div Infect Dis, David Geffen Sch Med, Los Angeles, CA 90095 USA

[2] UCLA Hlth, Clin Epidemiol & Infect Prevent, Los Angeles, CA 90095 USA

[3] UCLA, Dept Pediat, Div Pediat Infect Dis, David Geffen Sch Med, Los Angeles, CA USA

[4] UCLA, Dept Pathol & Lab Med, David Geffen Sch Med, Los Angeles, CA USA

来源：

INFECTION CONTROL & HOSPITAL EPIDEMIOLOGY | 2025年 / 46卷 / 05期

关键词：

Karius test; microbial cell-free DNA; surveillance; fungal diagnostics;

D O I：

10.1017/ice.2025.48

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Surveillance by clinical epidemiology teams for invasive fungal infections (IFIs) in healthcare settings can be challenging due to several factors including low sensitivity of noninvasive conventional microbiologic diagnostics, nonspecific clinical presentation, and complex patient populations. Recently, availability of microbial cell-free DNA testing (cfDNA) via the Karius Test has shown promise for increased diagnostic sensitivity of IFIs. However, how to best incorporate cfDNA results into IFI surveillance remains a vexing challenge. Herein, we provide perspectives on the benefits and challenges of use of cfDNA for IFI surveillance.

引用

页码：445 / 448

页数：4

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