Calcium Sulfate Bone Substitutes in Clinical Use: History, Material Properties, Application, and Outlook for the Future

被引：0
作者：
Straub, Josina [1 ]
Sewing, Andreas [2 ]
Walter, Nike [1 ]
Wong, Ronald Man Yeung [3 ]
Alt, Volker [1 ]
Heiss, Christian [4 ,5 ]
Rupp, Markus [4 ]
机构：
[1] Univ Hosp Regensburg, Dept Trauma Surg, Regensburg, Germany
[2] Osartis GmbH, Obernburg, Germany
[3] Chinese Univ Hong Kong, Dept Orthopaed & Traumatol, Hong Kong, Peoples R China
[4] Univ Hosp Giessen, Dept Trauma Hand & Reconstruct Surg, Giessen, Germany
[5] Biruni Univ, Istanbul, Turkiye
来源：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS | 2025年 / 113卷 / 04期
关键词：
available products; biomaterials; bone substitutes; calcium sulfate; CHRONIC OSTEOMYELITIS; LOCAL-DELIVERY; VOID FILLER; IN-VITRO; DEFECTS; PLASTER; PARIS; HYDROXYAPATITE; ARTHROPLASTY; ANTIBIOTICS;
D O I：
10.1002/jbm.b.35555
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Calcium sulfate-based materials have been used in medicine since the 19th century. Their application makes a significant part in the field of bone regeneration in biomedical engineering. Calcium sulfate is a versatile product that is used not only in the reconstruction of bone defects but also as an antibiotic carrier. Various types of calcium sulfate-based bone grafts have demonstrated their safety, well-tolerance, biodegradability, and osteoconductive properties, making them a potential substitute for autogenous bone transplant in the treatment of bone defects. Calcium sulfate and different-sized calcium sulfate beads can be produced and loaded with different antimicrobial substances. High concentrations of antimicrobial agents can be obtained by applying these locally to affected tissue. This review aims to (1) highlight the development and milestones already achieved in the use of calcium sulfate products and (2) outline the material properties and application areas with their related advantages and disadvantages of calcium sulfate products. Lastly, (3) an outlook for the future of calcium sulfate-based biomaterials is given.
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页数：10
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