Assessment of clouding behaviour and physico-chemical parameters of triton X-100 and metformin hydrochloride drug mixture: Understanding the impacts of hydrotropic compounds

被引：0

作者：

Maya, Sharmin Akhter ^{[1
]}

Hasan, Tajmul ^{[2
]}

Alam, Mahbub ^{[2
]}

Khan, Javed Masood ^{[3
]}

Amir, Mohammad ^{[4
]}

Rana, Shahed ^{[1
]}

Hoque, Md. Anamul ^{[1
]}

Rahman, Mohammad Majibur ^{[5
]}

Khan, Mohammed Abdullah ^{[1
]}

Islam, Amjad ^{[6
]}

机构：

[1] Jahangirnagar Univ, Dept Chem, Savar 1342, Dhaka, Bangladesh

[2] Bangladesh Army Univ Sci & Technol Khulna, Dept Chem, Khulna 9204, Khulna, Bangladesh

[3] King Saud Univ, Coll Food & Agr Sci, Dept Food Sci & Nutr, Riyadh 11451, Saudi Arabia

[4] Lovely Profess Univ, Sch Agr, Dept Genet & Plant Breeding, Phagwara, Punjab, India

[5] Jahangirnagar Univ, Dept Environm Sci, Savar 1342, Dhaka, Bangladesh

[6] Shantou Univ, Coll Chem & Chem Engn, Key Lab Preparat & Applicat Ordered Struct Mat Gua, Shantou, Guangdong, Peoples R China

来源：

JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2025年 / 102卷 / 03期

关键词：

Phase separation; Metformin hydrochloride; Thermodynamic parameters; Hydrotropes; Molar heat capacity; TX-100; CRITICAL MICELLE CONCENTRATION; ENTHALPY-ENTROPY COMPENSATION; NONIONIC SURFACTANT MIXTURES; PHASE-SEPARATION; AQUEOUS-SOLUTIONS; MICELLIZATION; ADDITIVES; POINT; WATER; UREA;

D O I：

10.1016/j.jics.2025.101608

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The study of the effect of various hydrotropes (HYTs) on the clouding behaviour of surfactant-drug mixture is imperative to enhance the pharmaceutical preparation. The hydrophobic nature of organic compounds demands a rigorous approach to boost the solubility of sparingly soluble drugs or organic molecules in aqueous solvents. Hydrotropes (HYTs) could be a unique selection to improve the liquid solubility of drugs that are not much soluble in water. In order to investigate the liquid solubility of surfactant and drug, the cloud point (CP) or lower consolute temperature (LCT) detection technique was used to examine the clouding phenomenon of Triton X-100 (TX-100) and metformin hydrochloride (MMH) mixed system in aqueous solutions of HYTs (o-cresol, caffeine, nicotinamide, urea, and glycerol). The CP values of TX-100 + MMH drug mixture are increased in the presence of caffeine, nicotinamide, and urea whereas the CP values decreased in presence of o-cresol and glycerol. In the current investigation, the values of Gibbs free energy (Delta G0c) were observed positive, so the clouding process was of TX-100 + MNH mixture nonspontaneous. But, when the HYT concentration rose, these values progressively experienced a drop. In aqueous HYTs media, the entropy change (Delta S0c) was positive (except o-cresol, and glycerol), as well as the enthalpy change (Delta H0c) was also found positive (except o-cresol, and glycerol). The Delta Hc0 and Delta S0c results indicate that intermolecular interactions, such as hydrogen bonding, dispersion forces, Debye forces, dipole-dipole interactions, as well as hydrophobic interactions, are the main forces between TX-100 + MMH in the presence of HYTs. The molar heat capacity ( Delta C0 ), compensation temperature (Tc), and intrinsic c enthalpy gain (Delta H0,* c ) were also computed and logically interpreted. Comprehending the surfactant-drug interaction is essential for developing efficient drug formulations and enhancing the surfactant-drug system for broad- ranges of industrial applications.

引用

页数：11

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