Clinical criteria for limbic-predominant age-related TDP-43 encephalopathy

被引：13

作者：

Wolk, David A. ^{[1
]}

Nelson, Peter T. ^{[2
]}

Apostolova, Liana ^{[3
]}

Arfanakis, Konstantinos ^{[4
,5
]}

Boyle, Patricia A. ^{[4
]}

Carlsson, Cynthia M. ^{[6
]}

Corriveau-Lecavalier, Nick ^{[7
]}

Dacks, Penny ^{[8
]}

Dickerson, Bradford C. ^{[9
]}

Domoto-Reilly, Kimiko ^{[10
]}

Dugger, Brittany N. ^{[11
]}

Edelmayer, Rebecca ^{[12
]}

Fardo, David W. ^{[2
]}

Grothe, Michel J. ^{[13
]}

Hohman, Timothy J. ^{[14
]}

Irwin, David J. ^{[1
]}

Jicha, Gregory A. ^{[2
]}

Jones, David T. ^{[7
]}

Kawas, Claudia H. ^{[15
]}

Lee, Edward B. ^{[1
]}

Lincoln, Karen ^{[15
]}

Maestre, Gladys E. ^{[16
]}

Mormino, Elizabeth C. ^{[17
]}

Onyike, Chiadi U. ^{[18
]}

Petersen, Ronald C. ^{[7
]}

Rabinovici, Gil D. ^{[19
]}

Rademakers, Rosa ^{[20
,21
]}

Raman, Rema ^{[22
]}

Rascovsky, Katya ^{[1
]}

Rissman, Robert A. ^{[23
]}

Rogalski, Emily ^{[24
]}

Scheltens, Philip ^{[25
]}

Sperling, Reisa A. ^{[26
]}

Yang, Hyun-Sik ^{[26
]}

Yu, Lei ^{[4
]}

Zetterberg, Henrik ^{[6
,27
,28
]}

Schneider, Julie A. ^{[4
]}

机构：

[1] Univ Penn, Philadelphia, PA USA

[2] Univ Kentucky, Lexington, KY USA

[3] Indiana Univ Sch Med, Indianapolis, IN USA

[4] Rush Univ, Med Ctr, Chicago, IL USA

[5] IIT, Chicago, IL USA

[6] Univ Wisconsin, Madison, WI USA

[7] Mayo Clin, Rochester, MN USA

[8] Assoc Frontotemporal Degenerat, King Of Prussia, PA USA

[9] Harvard Univ, Massachusetts Gen Hosp, Boston, MA 02115 USA

[10] Univ Washington, Dept Radiol, Seattle, WA 98195 USA

[11] Univ Calif Sacramento, Sacramento, CA USA

[12] Alzheimers Assoc, Chicago, IL USA

[13] CIEN Fdn, Reina Sofia Alzheimer Ctr, Madrid, Spain

[14] Vanderbilt Univ, Nashville, TN USA

[15] Univ Calif Irvine, Irvine, CA USA

[16] Univ Texas Rio Grande Valley, Brownsville, TX USA

[17] Stanford Univ, Palo Alto, CA USA

[18] Johns Hopkins Univ, Baltimore, MD USA

[19] Univ Calif San Francisco, San Francisco, CA USA

[20] VIB Ctr Mol Neurol, Antwerp, Belgium

[21] Univ Antwerp, Antwerp, Belgium

[22] Univ Southern Calif, Alzheimers Therapeut Res Inst, San Diego, CA USA

[23] Univ Calif La Jolla, La Jolla, CA USA

[24] Univ Chicago, Hlth Aging & Alzheimers Res Care HAARC Ctr, Dept Neurol, Chicago, IL USA

[25] Amsterdam Univ Med Ctr, Amsterdam, Netherlands

[26] Harvard Med Sch, Brigham & Womens Hosp, Massachusetts Gen Hosp, Boston, MA 02115 USA

[27] Univ Gothenburg, Gothenburg, Sweden

[28] UCL, Inst Neurol, London, England

来源：

ALZHEIMERS & DEMENTIA | 2025年 / 21卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; dementia; limbic predominant age-related TDP-43 encephalopathy; mild cognitive impairment; multi-etiology dementia; ALZHEIMERS ASSOCIATION WORKGROUPS; MILD COGNITIVE IMPAIRMENT; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; HIPPOCAMPAL ATROPHY; TAU PET; DISEASE; PATHOLOGY; RECOMMENDATIONS; PROTEINOPATHY;

D O I：

10.1002/alz.14202

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Limbic predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is highly prevalent in late life and a common co-pathology with Alzheimer's disease neuropathologic change (ADNC). LATE-NC is a slowly progressive, amnestic clinical syndrome. Alternatively, when present with ADNC, LATE-NC is associated with a more rapid course. With the emergence of anti-amyloid therapeutics, discrimination of LATE-NC from ADNC is critical and will lead to greater clinical recognition of amnestic patients without ADNC. Furthermore, co-pathology with LATE-NC may influence outcomes of these therapeutics. Thus there is a need to identify patients during life with likely LATE-NC. We propose criteria for clinical diagnosis of LATE as an initial framework for further validation. In the context of progressive memory loss and substantial hippocampal atrophy, criteria are laid out for probable (amyloid negative) or possible LATE (amyloid biomarkers are unavailable or when amyloid is present, but hippocampal neurodegeneration is out of proportion to expected pure ADNC).

引用

页数：13

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