Recent advances in organic fluorescent probes for detecting phosgene, mustard gas, nerve agents and their mimics

被引：0
作者：
Yang, Yang [1 ]
Bao, Xiaoying [1 ]
Shao, Yuxin [1 ]
Gao, Chao-Ying [1 ]
机构：
[1] Inner Mongolia Minzu Univ, Coll Chem & Mat Sci, Inner Mongolia Key Lab Nat Prod Chem & Funct Mol S, Tongliao 028000, Peoples R China
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2025年 / 332卷
基金：
中国国家自然科学基金;
关键词：
Chemical warfare agents; Fluorescent probes; Detection limits; Response time; Test strips; AGGREGATION-INDUCED EMISSION; DUAL-CHANNEL DISCRIMINATION; CHEMICAL WARFARE AGENTS; SENSITIVE DETECTION; FLUOROGENIC DETECTION; SELECTIVE DETECTION; SULFUR MUSTARD; SENSOR; CHEMODOSIMETER; CHEMOSENSOR;
D O I：
10.1016/j.saa.2025.125815
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Chemical warfare agents (CWAs) have been notorious for a century, especially sarin and mustard gas, which have produced intolerable menace to civilian lives and environmental security. As a result, developing simple, rapid, portable, sensitive, and selective detection technologies for CWAs is critical. This review primarily covered the recent progress in developing organic fluorescent probes for detecting phosgene, mustard gas, and nerve agents and their mimics. The review mainly discussed various sensing reactions utilized in the covalent strategies like cyclization, elimination, phosphorylation, alkylation, and sprioring-opening reaction, as well as the supramolecular approaches. The comparison of these probes highlighted the successful development of fluorescent probes for CWAs, some with detection limits in nano mol/L in solution and ppb scale in vapor state within seconds. These will contribute to a more effective system for detecting and monitoring CWAs in the future and improve the ability to respond to chemical attacks. Finally, the review discussed the limitations of current probes, emphasizing the need for on-site and real-time detection. It also called for research into new mechanisms and kits for rapid early warning of various CWAs to facilitate emergency handling and decontamination.
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页数：18
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  • [11] Zhu B., Sheng R., Chen T., Rodrigues J., Song Q.H., Hu X., Zeng L., Molecular engineered optical probes for chemical warfare agents and their mimics: Advances, challenges and perspectives, Coord. Chem. Rev., 463, (2022)
  • [12] Hu X., Ke Y., Ye H., Zhu B., Rodrigues J., Sheng R., Toward public security monitoring: A perspective of optical molecular probes for phosgene and mustard gas detection, Dyes Pigments, 216, (2023)
  • [13] Meng W.Q., Sedgwick A.C., Kwon N., Sun M., Xiao K., He X.P., Anslyn E.V., James T.D., Yoon J., Fluorescent probes for the detection of chemical warfare agents, Chem. Soc. Rev., 52, pp. 601-662, (2023)
  • [14] Chen Q., Sun Y., Liu S., Zhang J., Zhang C., Jiang H., Han X., He L., Wang S., Zhang K., Colorimetric and fluorescent sensors for detection of nerve agents and organophosphorus pesticides, Sens. Actuators B-Chem, 344, (2021)
  • [15] Li B., Fu Y., Cheng J., Fluorescent probes for detection of organophosphorus nerve agents and simulants, Prog. Chem., 33, pp. 1461-1472, (2021)
  • [16] Safarkhani M., Kim H., Han S., Taghavimandi F., Park Y., Umapathi R., Jeong Y.-S., Shin K., Huh Y.S., Advances in sprayable sensors for nerve agent detection, Coord. Chem. Rev., 509, (2024)
  • [17] Numan A., Singh P.S., Alam A., Khalid M., Li L., Singh S., Advances in Noble-Metal Nanoparticle-Based Fluorescence Detection of Organophosphorus Chemical Warfare Agents, ACS Omega, 7, pp. 27079-27089, (2022)
  • [18] Puglisi R., Santonocito R., Pappalardo A., (2024)
  • [19] Couzon N., Dhainaut J., Campagne C., Royer S., Loiseau T., Volkringer C., Porous textile composites (PTCs) for the removal and the decomposition of chemical warfare agents (CWAs)-A review, Coord. Chem. Rev., 467, (2022)
  • [20] Bobbitt N.S., Mendonca M.L., Howarth A.J., Islamoglu T., Hupp J.T., Farha O.K., Snurr R.Q., Metal-organic frameworks for the removal of toxic industrial chemicals and chemical warfare agents, Chem. Soc. Rev., 46, pp. 3357-3385, (2017)
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