Recent advances in organic fluorescent probes for detecting phosgene, mustard gas, nerve agents and their mimics

被引：0
作者：
Yang, Yang [1 ]
Bao, Xiaoying [1 ]
Shao, Yuxin [1 ]
Gao, Chao-Ying [1 ]
机构：
[1] Inner Mongolia Minzu Univ, Coll Chem & Mat Sci, Inner Mongolia Key Lab Nat Prod Chem & Funct Mol S, Tongliao 028000, Peoples R China
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2025年 / 332卷
基金：
中国国家自然科学基金;
关键词：
Chemical warfare agents; Fluorescent probes; Detection limits; Response time; Test strips; AGGREGATION-INDUCED EMISSION; DUAL-CHANNEL DISCRIMINATION; CHEMICAL WARFARE AGENTS; SENSITIVE DETECTION; FLUOROGENIC DETECTION; SELECTIVE DETECTION; SULFUR MUSTARD; SENSOR; CHEMODOSIMETER; CHEMOSENSOR;
D O I：
10.1016/j.saa.2025.125815
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Chemical warfare agents (CWAs) have been notorious for a century, especially sarin and mustard gas, which have produced intolerable menace to civilian lives and environmental security. As a result, developing simple, rapid, portable, sensitive, and selective detection technologies for CWAs is critical. This review primarily covered the recent progress in developing organic fluorescent probes for detecting phosgene, mustard gas, and nerve agents and their mimics. The review mainly discussed various sensing reactions utilized in the covalent strategies like cyclization, elimination, phosphorylation, alkylation, and sprioring-opening reaction, as well as the supramolecular approaches. The comparison of these probes highlighted the successful development of fluorescent probes for CWAs, some with detection limits in nano mol/L in solution and ppb scale in vapor state within seconds. These will contribute to a more effective system for detecting and monitoring CWAs in the future and improve the ability to respond to chemical attacks. Finally, the review discussed the limitations of current probes, emphasizing the need for on-site and real-time detection. It also called for research into new mechanisms and kits for rapid early warning of various CWAs to facilitate emergency handling and decontamination.
引用
收藏
页数：18
相关论文
共 159 条
  • [1] (2015)
  • [2] Picard B., Chataigner I., Maddaluno J., Legros J., Introduction to chemical warfare agents, relevant simulants and modern neutralisation methods, Org. Biomol. Chem., 17, pp. 6528-6537, (2019)
  • [3] Paimard G., Nejatian M., Sarlak Z., Mohammadi R., Rouhi M., Detection and qualification of nerve agent mimics, Microchem. J., 198, (2024)
  • [4] Sambrook M.R., Notman S., Supramolecular chemistry and chemical warfare agents: from fundamentals of recognition to catalysis and sensing, Chem. Soc. Rev., 42, pp. 9251-9267, (2013)
  • [5] Diehl K.L., Anslyn E.V., Array sensing using optical methods for detection of chemical and biological hazards, Chem. Soc. Rev., 42, pp. 8596-8611, (2013)
  • [6] Fan S., Zhang G., Dennison G.H., FitzGerald N., Burn P.L., Gentle I.R., Shaw P.E., Challenges in fluorescence detection of chemical warfare agent vapors using solid‐state films, Adv. Mater., 32, (2020)
  • [7] Singh V.V., Wang J., Nano/micromotors for security/defense applications, A Review, Nanoscale, 7, pp. 19377-19389, (2015)
  • [8] Burnworth M., Rowan S.J., Weder C., Fluorescent sensors for the detection of chemical warfare agents, Chem.-Eur. J., 13, pp. 7828-7836, (2007)
  • [9] Chen L., Wu D., Yoon J., Recent advances in the development of chromophore-based chemosensors for nerve agents and phosgene, ACS Sensors, 3, pp. 27-43, (2018)
  • [10] Gori M., Thakur A., Sharma A., Flora S.J.S., Organic-molecule-based fluorescent chemosensor for nerve agents and organophosphorus pesticides, Top. Curr. Chem., 379, (2021)
12345678910