Endothelial Colony-Forming Cells (ECFCs) in cerebrovascular aging: Focus on the pathogenesis of Vascular Cognitive Impairment and Dementia (VCID), and treatment prospects

被引：0

作者：

Negri, Sharon ^{[1
,2
]}

Reyff, Zeke ^{[1
,2
]}

Troyano-Rodriguez, Eva ^{[1
,2
]}

Milan, Madison ^{[1
,2
]}

Ihuoma, Jennifer ^{[1
,2
]}

Tavakol, Sherwin ^{[1
]}

Shi, Helen ^{[1
]}

Patai, Roland ^{[1
,2
]}

Jiang, Raymond ^{[1
,4
]}

Mohon, Jonah ^{[1
,3
]}

Boma-Iyaye, Jed ^{[1
,3
]}

Ungvari, Zoltan ^{[1
,5
,6
]}

Csiszar, Anna ^{[1
]}

Yabluchanskiy, Andriy ^{[1
,2
,6
]}

Moccia, Francesco ^{[7
]}

Tarantini, Stefano ^{[1
,2
,5
,6
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Neurosurg, Vasc Cognit Impairment & Neurodegenerat Program, Oklahoma City, OK USA

[2] Univ Oklahoma, Hlth Sci Ctr, Stephenson Canc Ctr, Oklahoma City, OK USA

[3] Oklahoma Sch Sci & Math, Oklahoma City, OK USA

[4] Casady Sch, Oklahoma City, OK USA

[5] Semmelweis Univ, Inst Prevent Med & Publ Hlth, Doctoral Coll, Int Training Program Gerosci,Hlth Sci Program, Budapest, Hungary

[6] Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth, Dept Hlth Promot Sci, Oklahoma City, OK USA

[7] Univ Molise, Dept Med & Hlth Sci V Tiberio, I-86100 Campobasso, Italy

来源：

AGEING RESEARCH REVIEWS | 2025年 / 104卷

关键词：

Endothelial Colony-Forming cells; Angiogenesis; Blood brain barrier; Neuroinflammation; Oxidative stress; Vascular regeneration; Cerebral blood flow; BLOOD-BRAIN-BARRIER; UMBILICAL-CORD BLOOD; PROGENITOR CELLS; IN-VIVO; OXIDATIVE STRESS; ALZHEIMERS-DISEASE; PERIPHERAL-BLOOD; MURINE MODEL; DYSFUNCTION; OUTGROWTH;

D O I：

10.1016/j.arr.2025.102672

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Endothelial colony-forming cells (ECFCs), a unique endothelial progenitor subset, are essential for vascular integrity and repair, providing significant regenerative potential. Recent studies highlight their role in cerebrovascular aging, particularly in the pathogenesis of vascular cognitive impairment and dementia (VCID). Aging disrupts ECFC functionality through mechanisms such as oxidative stress, chronic inflammation, and cellular senescence, leading to compromised vascular repair and reduced neurovascular resilience. ECFCs influence key cerebrovascular processes, including neurovascular coupling (NVC), blood-brain barrier (BBB) integrity, and vascular regeneration, which are critical for cognitive health. Age-related decline in ECFC quantity and functionality contributes to vascular rarefaction, diminished cerebral blood flow (CBF), and BBB permeability-processes that collectively exacerbate cognitive decline. This review delves into the multifaceted role of ECFCs in cerebrovascular aging and underscores their potential as therapeutic targets in addressing age- related vascular dysfunctions, presenting new directions for mitigating the effects of aging on brain health.

引用

页数：14

共 131 条

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