CC chemokine receptor 5 and CC chemokine ligand 5 gene polymorphisms in patients with periodontitis - A case-control study

Aim: This study aimed to evaluate the association of CC Chemokine Receptor 5 (CCR5) G59029A and CC Chemokine Ligand 5 (CCL5) -28 C/G gene polymorphisms in patients with and without periodontitis. Materials and methods: A total of 172 individuals were enrolled, divided into two groups: Group I (periodontally healthy, n = 86) and Group II (generalized chronic periodontitis, n = 86). Periodontal clinical parameters such as Periodontal Probing Depth (PPD), Clinical Attachment Loss (CAL), Plaque Index (PI), and Bleeding Index (BI) were recorded. Allele-specific PCR (AS-PCR) was used to identify polymorphic sites in the CCL5 and CCR5 genes. Results: The heterozygous genotype CG and allele G was more prevalent in the Test group (p value = 0.001, 0.01) for CCL5 gene polymorphism. Similarly, the heterozygous genotype AG and allele G for CCR5 gene polymorphism was significantly higher in the Test group (p value = 0.002, 0.04). Conclusion: The study found a significant association between CCL5 and CCR5 gene polymorphisms and periodontitis.