Synthesis, Characterization, DFT, TEM, Anticancer, Antibacterial, and Electrical Properties Studies of Novel VO(II), Cu(II), Ru(III), and Ag(I) Complexes With Hydrazone Derivatives

被引：0
作者：
Abdalla, Ehab M. [1 ]
Aly, Samar A. [2 ]
Salama, Alia H. [3 ]
Hassan, Safaa S. [4 ]
Mongy, Ahmed M. [5 ]
Salem, Tarek A. [6 ]
Khalf-Alla, Perihan A. [4 ]
机构：
[1] New Valley Univ, Fac Sci, Chem Dept, Alkharga, Egypt
[2] Univ Sadat City, Genet Engn & Biotechnol Res Inst, Dept Environm Biotechnol, Sadat City, Egypt
[3] Natl Res Ctr, Dept Chem, El Doki, Egypt
[4] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt
[5] New Mansoura Univ, Fac Dent, New Mansoura, Egypt
[6] Qassim Univ, Coll Med, Dept Biochem, Buraydah, Saudi Arabia
来源：
APPLIED ORGANOMETALLIC CHEMISTRY | 2025年 / 39卷 / 03期
关键词：
antibacterial; anticancer; complexes; DFT; electrical properties; TEM; METAL-COMPLEXES; CONDUCTIVITY; SUBSTITUTION; COPPER(II); ACETONE; DNA;
D O I：
10.1002/aoc.70073
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Four new VO(II), Cu(II), Ru(III), and Ag(I) chelates were created from the ligand, 2-(phenylglycyl)-N-(p-tolyl)hydrazine-1-carbothioamide(H2L). The structures of the new compounds were investigated using analytical and spectroscopic techniques and supported by the theoretical DFT study. In addition, all compounds exhibited strong anticancer effects against liver (Hep-G2), breast (MCF-7), and colon (HCT-116) human cancer cell lines. VO(II) complex observed the greatest activity with IC50 reached to 14, 19, and 20 mu M against Hep-G2, MCF-7, and HCT-116 cell lines, respectively. Molecular docking confirmed the resulted anticancer results. Also, the compounds observed microbial growth inhibition against S. pyogenes and E. coli organisms. The transmission electron microscope (TEM) demonstrated that the pure ligand's particle size decreased when it formed complexes with various metals. The electrical examination of complexes involved measuring their conductivity and dielectric characteristics to explore their application in electrical devices.
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页数：17
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