The Diagnosis and Evolution of Patients with LARS Syndrome: A Five-Year Retrospective Study from a Single Surgery Unit

被引:1
作者
Obleaga, Cosmin Vasile [1 ]
Cazacu, Sergiu Marian [2 ]
Cojan, Tiberiu Stefanita Tenea [1 ]
Mirea, Cecil Sorin [1 ]
Florescu, Dan Nicolae [2 ]
Constantin, Cristian [2 ]
Serbanescu, Mircea-Sebastian [3 ]
Florescu, Mirela Marinela [4 ]
Streba, Liliana [5 ]
Popescu, Dragos Marian [6 ]
Vilcea, Ionica Daniel [1 ]
Ciorbagiu, Mihai Calin [1 ]
机构
[1] Univ Med & Pharm Craiova, Dept Surg, Craiova 200642, Romania
[2] Univ Med & Pharm Craiova, Dept Gastroenterol & Hepatol, Craiova 200349, Romania
[3] Univ Med & Pharm Craiova, Dept Med Informat, Craiova 200349, Romania
[4] Univ Med & Pharm Craiova, Dept Pathol, Craiova 200349, Romania
[5] Univ Med & Pharm Craiova, Dept Oncol, Craiova 200349, Romania
[6] Univ Med & Pharm Craiova, Dept Extreme Condit Med, Craiova 200349, Romania
关键词
low anterior rectal resection; rectal cancer; LARS; LOW ANTERIOR RESECTION; NEORECTUM; MOTILITY; DISORDER;
D O I
10.3390/cancers16244175
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objectives: The aim of the study was to assess the diagnosis and evolution of low anterior rectal resection syndrome (LARS) in patients admitted to a tertiary surgical center in Romania. Materials and Methods: From 120 patients initially included in the analysis, after applying the exclusion criteria, we selected 102 patients diagnosed and operated on for neoplasm of the upper, middle, and lower rectum for which resection and excision (partial or total) of mesorectum was associated. All the patients we treated in the general surgery department of the County Emergency Hospital of Craiova within a time frame of 5 years (1 October 2017-1 September 2022), and all experienced at least one symptom associated with LARS. The group included 68 men and 34 women aged between 35 and 88, who were followed-up for at least 2 years. Patients with progression of neoplastic disease, with advanced neurological disease, and those who died less than 2 years after surgery were excluded. Results: The overall incidence varied by gender, site of the tumor (requiring a certain type of surgery), and anastomotic complications, and it was directly proportional to the time interval between resection and restoration of continuity of digestion. Conclusions: Obesity, size of the remaining rectum, total excision of the mesorectum, anastomotic complications, and prolonged ileostomy time are cofactors in the etiology of LARS. The LARS score decreased in most patients during the 2-year follow-up, although there were a small number of patients in whom the decrease was insignificant. The persistence of major LARS at 6 months after surgery may predict the need for a definitive colostomy.
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页数:13
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