Association Between Glaucoma and Brain Structural Connectivity Based on Diffusion Tensor Tractography: A Bidirectional Mendelian Randomization Study

被引:0
作者
Shu, Lian [1 ]
Chen, Xiaoxiao [1 ]
Sun, Xinghuai [1 ,2 ,3 ,4 ,5 ]
机构
[1] Fudan Univ, Eye & ENT Hosp, Shanghai Med Coll, Dept Ophthalmol & Visual Sci, Shanghai 200031, Peoples R China
[2] Fudan Univ, Inst Brain Sci, State Key Lab Med Neurobiol, Shanghai 200032, Peoples R China
[3] Fudan Univ, Inst Brain Sci, MOE Frontiers Ctr Brain Sci, Shanghai 200032, Peoples R China
[4] Fudan Univ, Chinese Acad Med Sci, NHC Key Lab Myopia, Shanghai 200031, Peoples R China
[5] Fudan Univ, Shanghai Key Lab Visual Impairment & Restorat, Shanghai 200031, Peoples R China
基金
中国国家自然科学基金;
关键词
glaucoma; diffusion tensor tractography; diffusion tensor imaging; Mendelian randomization; structural connectivity; neurodegenerative disease; OPEN-ANGLE GLAUCOMA; WHITE-MATTER ABNORMALITIES; VISUAL PATHWAY; OPTIC-NERVE; SEVERITY; MODELS; BIAS; EYE;
D O I
10.3390/brainsci14101030
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Glaucoma is a neurodegenerative ocular disease that is accompanied by cerebral damage extending beyond the visual system. Recent studies based on diffusion tensor tractography have suggested an association between glaucoma and brain structural connectivity but have not clarified causality. Methods: To explore the causal associations between glaucoma and brain structural connectivity, a bidirectional Mendelian randomization (MR) study was conducted involving glaucoma and 206 diffusion tensor tractography traits. Highly associated genetic variations were applied as instrumental variables and statistical data were sourced from the database of FinnGen and UK Biobank. The inverse-variance weighted method was applied to assess causal relationships. Additional sensitivity analyses were also performed. Results: Glaucoma was potentially causally associated with alterations in three brain structural connectivities (from the SN to the thalamus, from the DAN to the putamen, and within the LN network) in the forward MR analysis, whereas the inverse MR results identified thirteen brain structural connectivity traits with a potential causal relationship to the risk of glaucoma. Both forward and reverse MR analyses satisfied the sensitivity test with no significant horizontal pleiotropy or heterogeneity. Conclusions: This study offered suggestive evidence for the potential causality between the risk of glaucoma and brain structural connectivity. Our findings also provided novel insights into the neurodegenerative mechanism of glaucoma.
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页数:13
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