Association Between Glaucoma and Brain Structural Connectivity Based on Diffusion Tensor Tractography: A Bidirectional Mendelian Randomization Study

被引:0
作者
Shu, Lian [1 ]
Chen, Xiaoxiao [1 ]
Sun, Xinghuai [1 ,2 ,3 ,4 ,5 ]
机构
[1] Fudan Univ, Eye & ENT Hosp, Shanghai Med Coll, Dept Ophthalmol & Visual Sci, Shanghai 200031, Peoples R China
[2] Fudan Univ, Inst Brain Sci, State Key Lab Med Neurobiol, Shanghai 200032, Peoples R China
[3] Fudan Univ, Inst Brain Sci, MOE Frontiers Ctr Brain Sci, Shanghai 200032, Peoples R China
[4] Fudan Univ, Chinese Acad Med Sci, NHC Key Lab Myopia, Shanghai 200031, Peoples R China
[5] Fudan Univ, Shanghai Key Lab Visual Impairment & Restorat, Shanghai 200031, Peoples R China
基金
中国国家自然科学基金;
关键词
glaucoma; diffusion tensor tractography; diffusion tensor imaging; Mendelian randomization; structural connectivity; neurodegenerative disease; OPEN-ANGLE GLAUCOMA; WHITE-MATTER ABNORMALITIES; VISUAL PATHWAY; OPTIC-NERVE; SEVERITY; MODELS; BIAS; EYE;
D O I
10.3390/brainsci14101030
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Glaucoma is a neurodegenerative ocular disease that is accompanied by cerebral damage extending beyond the visual system. Recent studies based on diffusion tensor tractography have suggested an association between glaucoma and brain structural connectivity but have not clarified causality. Methods: To explore the causal associations between glaucoma and brain structural connectivity, a bidirectional Mendelian randomization (MR) study was conducted involving glaucoma and 206 diffusion tensor tractography traits. Highly associated genetic variations were applied as instrumental variables and statistical data were sourced from the database of FinnGen and UK Biobank. The inverse-variance weighted method was applied to assess causal relationships. Additional sensitivity analyses were also performed. Results: Glaucoma was potentially causally associated with alterations in three brain structural connectivities (from the SN to the thalamus, from the DAN to the putamen, and within the LN network) in the forward MR analysis, whereas the inverse MR results identified thirteen brain structural connectivity traits with a potential causal relationship to the risk of glaucoma. Both forward and reverse MR analyses satisfied the sensitivity test with no significant horizontal pleiotropy or heterogeneity. Conclusions: This study offered suggestive evidence for the potential causality between the risk of glaucoma and brain structural connectivity. Our findings also provided novel insights into the neurodegenerative mechanism of glaucoma.
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页数:13
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共 85 条
  • [41] Exploring risk factors for autoimmune diseases complicated by non-hodgkin lymphoma through regulatory T cell immune-related traits: a Mendelian randomization study
    Liu, Qi
    Zhou, Xintong
    Liu, Kunjing
    Wang, Yimin
    Liu, Cun
    Gao, Chundi
    Cai, Qingqing
    Sun, Changgang
    [J]. FRONTIERS IN IMMUNOLOGY, 2024, 15
  • [42] Postoperative increase in grey matter volume in visual cortex after unilateral cataract surgery
    Lou, Astrid R.
    Madsen, Kristoffer H.
    Julian, Hanne O.
    Toft, Peter B.
    Kjaer, Troels W.
    Paulson, Olaf B.
    Prause, Jan U.
    Siebner, Hartwig R.
    [J]. ACTA OPHTHALMOLOGICA, 2013, 91 (01) : 58 - 65
  • [43] The challenge of mapping the human connectome based on diffusion tractography
    Maier-Hein, Klaus H.
    Neher, Peter F.
    Houde, Jean-Christophe
    Cote, Marc-Alexandre
    Garyfallidis, Eleftherios
    Zhong, Jidan
    Chamberland, Maxime
    Yeh, Fang-Cheng
    Lin, Ying-Chia
    Ji, Qing
    Reddick, Wilburn E.
    Glass, John O.
    Chen, David Qixiang
    Feng, Yuanjing
    Gao, Chengfeng
    Wu, Ye
    Ma, Jieyan
    Renjie, H.
    Li, Qiang
    Westin, Carl-Fredrik
    Deslauriers-Gauthier, Samuel
    Ocegueda Gonzalez, J. Omar
    Paquette, Michael
    St-Jean, Samuel
    Girard, Gabriel
    Rheault, Francois
    Sidhu, Jasmeen
    Tax, Chantal M. W.
    Guo, Fenghua
    Mesri, Hamed Y.
    David, Szabolcs
    Froeling, Martijn
    Heemskerk, Anneriet M.
    Leemans, Alexander
    Bore, Arnaud
    Pinsard, Basile
    Bedetti, Christophe
    Desrosiers, Matthieu
    Brambati, Simona
    Doyon, Julien
    Sarica, Alessia
    Vasta, Roberta
    Cerasa, Antonio
    Quattrone, Aldo
    Yeatman, Jason
    Khan, Ali R.
    Hodges, Wes
    Alexander, Simon
    Romascano, David
    Barakovic, Muhamed
    [J]. NATURE COMMUNICATIONS, 2017, 8
  • [44] MRI and Clinical Biomarkers Overlap between Glaucoma and Alzheimer's Disease
    Martucci, Alessio
    Di Giuliano, Francesca
    Minosse, Silvia
    Pocobelli, Giulio
    Nucci, Carlo
    Garaci, Francesco
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (19)
  • [45] Advanced Morphological and Functional Magnetic Resonance Techniques in Glaucoma
    Mastropasqua, Rodolfo
    Agnifili, Luca
    Mattei, Peter A.
    Caulo, Massimo
    Fasanella, Vincenzo
    Navarra, Riccardo
    Mastropasqua, Leonardo
    Marchini, Giorgio
    [J]. BIOMED RESEARCH INTERNATIONAL, 2015, 2015
  • [46] Advanced Diffusion MRI of the Visual System in Glaucoma: From Experimental Animal Models to Humans
    Mendoza, Monica
    Shotbolt, Max
    Faiq, Muneeb A.
    Parra, Carlos
    Chan, Kevin C.
    [J]. BIOLOGY-BASEL, 2022, 11 (03):
  • [47] Mendelian randomization analyses reveal causal relationships between brain functional networks and risk of psychiatric disorders
    Mu, Changgai
    Dang, Xinglun
    Luo, Xiong-Jian
    [J]. NATURE HUMAN BEHAVIOUR, 2024, 8 (07): : 1417 - 1428
  • [48] Associations of Irritability With Functional Connectivity of Amygdala and Nucleus Accumbens in Adolescents and Young Adults With ADHD
    Mukherjee, Prerona
    Vilgis, Veronika
    Rhoads, Shawn
    Chahal, Rajpreet
    Fassbender, Catherine
    Leibenluft, Ellen
    Dixon, J. Faye
    Pakyurek, Murat
    van den Bos, Wouter
    Hinshaw, Stephen P.
    Guyer, Amanda E.
    Schweitzer, Julie B.
    [J]. JOURNAL OF ATTENTION DISORDERS, 2022, 26 (07) : 1040 - 1050
  • [49] Evaluation of Retinal Nerve Fiber Layer Thickness, Electroretinogram and Visual Evoked Potential in Patients with Alzheimer's Disease
    Ngoo, Qi Zhe
    Hitam, Wan Hazabbah Wan
    Ab Razak, Asrenee
    [J]. JOURNAL OF OPHTHALMOLOGY, 2019, 2019
  • [50] Multi-Contrast Magnetic Resonance Imaging of Visual White Matter Pathways in Patients With Glaucoma
    Ogawa, Shumpei
    Takemura, Hiromasa
    Horiguchi, Hiroshi
    Miyazaki, Atsushi
    Matsumoto, Kenji
    Masuda, Yoichiro
    Yoshikawa, Keiji
    Nakano, Tadashi
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2022, 63 (02)