Sex differences in biomarkers and biologic mechanisms in psoriatic diseases and spondyloarthritis

被引：4

作者：

Dang, Steven ^{[1
]}

Wither, Joan ^{[2
,3
,4
,5
]}

Jurisica, Igor ^{[3
,6
,7
,8
]}

Chandran, Vinod ^{[1
,2
,3
,9
,10
]}

Eder, Lihi ^{[1
,2
]}

机构：

[1] Womens Coll Hosp, Toronto, ON, Canada

[2] Univ Toronto, Inst Med Sci, Toronto, ON, Canada

[3] Univ Toronto, Dept Med, Div Rheumatol, Toronto, ON, Canada

[4] Univ Hlth Network, Schroeder Arthrit Inst, Toronto, ON, Canada

[5] Univ Hlth Network, Krembil Res Inst, Toronto, ON, Canada

[6] Univ Toronto, Dept Immunol, Toronto, ON, Canada

[7] Univ Toronto, Dept Med Biophys & Comp Sci, Toronto, ON, Canada

[8] Univ Toronto, Fac Dent, Toronto, ON, Canada

[9] Slovak Acad Sci, Inst Neuroimmunol, Bratislava, Slovakia

[10] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

来源：

JOURNAL OF AUTOIMMUNITY | 2025年 / 152卷

基金：

加拿大创新基金会; 加拿大自然科学与工程研究理事会;

关键词：

Psoriatic arthritis; Psoriasis; Spondyloarthritis; Sex; Biomarkers; Biological pathways; OSTEOPROTEGERIN SERUM-LEVELS; BONE-MINERAL DENSITY; C-REACTIVE-PROTEIN; ANKYLOSING-SPONDYLITIS; AXIAL SPONDYLOARTHRITIS; GENDER-DIFFERENCES; ANIMAL-MODELS; RADIOGRAPHIC PROGRESSION; INSULIN SENSITIVITY; FEMALE-PATIENTS;

D O I：

10.1016/j.jaut.2025.103394

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Psoriasis and spondyloarthritis (SpA), including psoriatic arthritis (PsA), are immune-mediated inflammatory conditions that affect the skin and musculoskeletal system. Males and female patients with psoriatic disease and SpA exhibit differences in clinical presentation, disease progression, and treatment response. The underlying biological mechanisms driving these sex differences remain poorly understood. This review explores the current evidence on sex-related differences in biomarkers and biological pathways in psoriasis, PsA, and SpA. While no conclusive sex-specific biomarkers have been validated, this review highlights several sex-related differences in biomarkers and biological pathways, including differences in bone turnover markers, IL-23/IL-17 pathway activity, pro-inflammatory cytokines, and cardio-metabolic profiles that may partially contribute to the clinical differences observed between male and female patients. Sex hormones may contribute to the altered bone metabolism and immune regulation in females. To effectively identify and validate sex-specific biomarkers, there is a need to prioritize sex as a biological variable in future research. Adopting such an approach should enhance more personalized therapeutic strategies and improve management for male and female patients with psoriatic disease and SpA.

引用

页数：15

共 146 条

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