Integrative analysis disclosing UQCRC1 as a potential prognostic and immunological biomarker of lung adenocarcinoma

被引:0
作者
Ling, Lv [1 ]
Peng, Cong [1 ]
Lin, Sheng [1 ]
Chen, Yuanhang [1 ]
Deng, Min [1 ]
Qiu, Huisi [2 ]
Huang, Yuanfeng [1 ]
机构
[1] Guangzhou Med Univ, Affiliated Canc Hosp, Guangzhou Inst Canc Res, Hengzhigang Rd 78, Guangzhou 510095, Guangdong, Peoples R China
[2] Guangzhou Med Univ, Affiliated Qingyuan Hosp, Qingyuan 511518, Guangdong, Peoples R China
关键词
lung adenocarcinoma (LUAD); pan-cancer; prognosis; tumor immune infiltration; ubiquinol-cytochrome c reductase core protein 1 </span>(UQCRC1); OSTEOSARCOMA CELL; GENE-EXPRESSION; ASSOCIATION; CANCER;
D O I
10.1016/j.prp.2025.155816
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Lung cancer is one of the most malignant cancers in the world. Approximately 40 % of lung cancer cases are lung adenocarcinoma (LUAD). Exploring new biomarkers was an urgent need for treatments of LUAD. Here, we aimed to perform a pan-cancer analysis of ubiquinol-cytochrome c reductase core protein 1 (UQCRC1) and verify it in LUAD. Compared to normal samples, we observed that UQCRC1 was significantly enhanced in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), LUAD, liver hepatocellular carcinoma (LIHC), and several other cancers. In terms of overall survival, UQCRC1 was positively associated with poor prognosis of LUAD and skin cutaneous melanoma (SKCM). Almost more than 8 % deeply deleted frequency of UQCRC1 was showed in lymphoid neoplasm diffuse large B-cell lymphoma (DLBC). In LUAD, SKCM, and a few cancers, UQCRC1 was negatively correlated with the infiltration of B cells and cancer-associated fibroblasts. As regards further mechanism analysis, we found that UQCRC1 modulated cancer progression via mitochondrial related metabolism and oxidative phosphorylation. Taking advantage of the Kras-driven spontaneous LUAD mice model, online single-cell data, and clinical tissues, we particularly confirmed that UQCRC1 was highly expressed in LUAD and acted as a prognostic marker for LUAD. These findings implied that UQCRC1 played an important role in cancers, especially in LUAD.
引用
收藏
页数:12
相关论文
共 30 条
[1]   Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage [J].
Aran, Dvir ;
Looney, Agnieszka P. ;
Liu, Leqian ;
Wu, Esther ;
Fong, Valerie ;
Hsu, Austin ;
Chak, Suzanna ;
Naikawadi, Ram P. ;
Wolters, Paul J. ;
Abate, Adam R. ;
Butte, Atul J. ;
Bhattacharya, Mallar .
NATURE IMMUNOLOGY, 2019, 20 (02) :163-+
[2]   NEW CONCEPT FOR ENERGY COUPLING IN OXIDATIVE-PHOSPHORYLATION BASED ON A MOLECULAR EXPLANATION OF OXYGEN-EXCHANGE REACTIONS [J].
BOYER, PD ;
CROSS, RL ;
MOMSEN, W .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (10) :2837-2839
[3]   Liver stromal cells restrict macrophage maturation and stromal IL-6 limits the differentiation of cirrhosis-linked macrophages [J].
Buonomo, Erica L. ;
Mei, Shenglin ;
Guinn, Samantha R. ;
Leo, Isabelle R. ;
Peluso, Michael J. ;
Nolan, Mei-An ;
Schildberg, Frank A. ;
Zhao, Lei ;
Lian, Christine ;
Xu, Shuyun ;
Misdraji, Joseph ;
Kharchenko, Peter, V ;
Sharpe, Arlene H. .
JOURNAL OF HEPATOLOGY, 2022, 76 (05) :1127-1137
[4]   Quantitative proteomics identified circulating biomarkers in lung adenocarcinoma diagnosis [J].
Chen, Hongyu ;
Lai, Xiaoqin ;
Zhu, Yihan ;
Huang, Hong ;
Zeng, Lingyan ;
Zhang, Li .
CLINICAL PROTEOMICS, 2022, 19 (01)
[5]   Report of cancer incidence and mortality in China, 2010 [J].
Chen, Wanqing ;
Zheng, Rongshou ;
Zhang, Siwei ;
Zhao, Ping ;
Zeng, Hongmei ;
Zou, Xiaonong .
ANNALS OF TRANSLATIONAL MEDICINE, 2014, 2 (07)
[6]   Epithelial cells activate fibroblasts to promote esophageal cancer development [J].
Chen, Yamei ;
Zhu, Shihao ;
Liu, Tianyuan ;
Zhang, Shaosen ;
Lu, Junting ;
Fan, Wenyi ;
Lin, Lin ;
Xiang, Tao ;
Yang, Jie ;
Zhao, Xuan ;
Xi, Yiyi ;
Ma, Yuling ;
Cheng, Guoyu ;
Lin, Dongxin ;
Wu, Chen .
CANCER CELL, 2023, 41 (05) :903-+
[7]   Increased Expression of Mitochondrial UQCRC1 in Pancreatic Cancer Impairs Antitumor Immunity of Natural Killer Cells via Elevating Extracellular ATP [J].
Cong, Hui ;
Gao, Jian ;
Wang, Qing ;
Du, Min ;
Li, Huimin ;
Li, Qian ;
Li, Jin ;
Liang, Yiyi ;
Zhao, Dan ;
Yang, Hancao ;
Gan, Yu ;
Tu, Hong .
FRONTIERS IN ONCOLOGY, 2022, 12
[8]   Impact of immune cells on the hallmarks of cancer: A literature review [J].
Costa, Alexandra C. ;
Santos, Joana M. O. ;
da Costa, Rui M. Gil ;
Medeiros, Rui .
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2021, 168
[9]   Single-cell atlas reveals a distinct immune profile fostered by T cell-B cell crosstalk in triple negative breast cancer [J].
Ding, Shuning ;
Qiao, Niu ;
Zhu, Qingchen ;
Tong, Yiwei ;
Wang, Shengyue ;
Chen, Xiaosong ;
Tian, Qiang ;
Xiao, Yichuan ;
Shen, Kunwei .
CANCER COMMUNICATIONS, 2023, 43 (06) :661-684
[10]   Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment [J].
Dinh, Huy Q. ;
Pan, Feng ;
Wang, Geng ;
Huang, Qing-Feng ;
Olingy, Claire E. ;
Wu, Zhi-Yong ;
Wang, Shao-Hong ;
Xu, Xin ;
Xu, Xiu-E ;
He, Jian-Zhong ;
Yang, Qian ;
Orsulic, Sandra ;
Haro, Marcela ;
Li, Li-Yan ;
Huang, Guo-Wei ;
Breunig, Joshua J. ;
Koeffler, H. Phillip ;
Hedrick, Catherine C. ;
Xu, Li-Yan ;
Lin, De-Chen ;
Li, En-Min .
NATURE COMMUNICATIONS, 2021, 12 (01)