Hepatitis C Virus-Core Antigen: Implications in Diagnostic, Treatment Monitoring and Clinical Outcomes

被引：0
作者：
Le, Duong Hoang Huy [1 ,2 ,3 ]
Kanokudom, Sitthichai [1 ,2 ]
Nguyen, Ha Minh [3 ,4 ]
Yorsaeng, Ritthideach [1 ]
Honsawek, Sittisak [2 ]
Vongpunsawad, Sompong [1 ]
Poovorawan, Yong [1 ,5 ]
机构：
[1] Chulalongkorn Univ, Fac Med, Ctr Excellence Clin Virol, Dept Pediat, Bangkok 10330, Thailand
[2] Chulalongkorn Univ, King Chulalongkorn Mem Hosp, Fac Med, Ctr Excellence Osteoarthritis & Musculoskeleton, Bangkok 10330, Thailand
[3] Pham Ngoc Thach Univ Med, Med Biochem & Mol Biol Dept, Fundamental Sci & Basic Med Sci, Ho Chi Minh City 700000, Vietnam
[4] Nguyen Tri Phuong Hosp, Lab Dept, Ho Chi Minh City 700000, Vietnam
[5] Royal Soc Thailand, Bangkok 10330, Thailand
来源：
VIRUSES-BASEL | 2024年 / 16卷 / 12期
关键词：
hepatitis C virus; HCV core antigen; diagnostics; HCV treatment; monitoring; resource-limited settings; global elimination strategies; DIRECT-ACTING ANTIVIRALS; HCV RNA; INFECTION; ASSAY; PROTEIN; MANAGEMENT; LIVER; QUANTIFICATION; PERFORMANCE; EXPRESSION;
D O I：
10.3390/v16121863
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The hepatitis C virus (HCV) infection, a global health concern, can lead to chronic liver disease. The HCV core antigen (HCVcAg), a viral protein essential for replication, offers a cost-effective alternative to HCV RNA testing, particularly in resource-limited settings. This review explores the significance of HCVcAg, a key protein in the hepatitis C virus, examining its structure, function, and role in the viral life cycle. It also evaluates its clinical use in diagnosis and treatment monitoring, comparing its performance to the standard HCV RNA assay using data from PubMed and Google Scholar. HCVcAg assays show high pooled sensitivity (93.5%) and pooled specificity (99.2%) compared to HCV RNA assays, correlating closely (r = 0.87) with HCV RNA levels. Hence, HCVcAg testing offers a cost-effective way to diagnose active HCV infections and monitor treatment, especially in resource-limited settings, but its sensitivity can vary and standardization is needed. HCVcAg also predicts liver disease progression and assesses liver damage risk, aiding patient management. It helps to identify patients at risk for fibrosis or carcinoma, making it vital in hepatitis C care. HCVcAg testing can expand access to HCV care, simplify management, and contribute to global elimination strategies, especially in low- and middle-income countries.
引用
收藏
页数：36
相关论文
共 120 条
  • [61] Florea D., Neaga E., Nicolae I., Maxim D., Popa M., Otelea D., Clinical usefulness of HCV core antigen assay for the management of patients with chronic hepatitis C, J. Gastrointest. Liver Dis, 23, pp. 393-396, (2014)
  • [62] Garbuglia A.R., Monachetti A., Galli C., Sabatini R., Ferreri M.L., Capobianchi M.R., Bagnarelli P., HCV core antigen and HCV-RNA in HIV/HCV co-infected patients with different HCV genotypes, BMC Infect. Dis, 14, (2014)
  • [63] Kadkhoda K., Smart G., HCV antigen testing for the diagnosis of hepatitis C infection: A cost-efficient algorithm, Clin. Lab, 60, pp. 677-680, (2014)
  • [64] Reyes-Mendez M.A., Juarez-Figueroa L., Iracheta-Hernandez P., Medina-Islas Y., Ruiz-Gonzalez V., Comparison of two diagnostic algorithms for the identification of patients with HCV viremia using a new HCV antigen test, Ann. Hepatol, 13, pp. 337-342, (2014)
  • [65] van Helden J., Weiskirchen R., Hepatitis C diagnostics: Clinical evaluation of the HCV-core antigen determination, Z Gastroenterol, 52, pp. 1164-1170, (2014)
  • [66] Kamal S., Kassim S., El Gohary E., Fouad A., Nabegh L., Hafez T., Bahnasy K., Hassan H., Ghoraba D., The accuracy and cost-effectiveness of hepatitis C core antigen assay in the monitoring of anti-viral therapy in patients with chronic hepatitis C genotype 4, Aliment. Pharmacol. Ther, 42, pp. 307-318, (2015)
  • [67] Feyzioglu B., Baysal B., Demircili M.E., Ozdemir M., The Efficiency of Hepatitis C Virus Core Antigen Test in the Diagnosis of Hepatitis C Infection, J. Viral Hepat, 1, pp. 18-22, (2016)
  • [68] Alonso R., Perez-Garcia F., Ampuero D., Reigadas E., Bouza E., New direct-acting antivirals for patients with chronic HCV infection: Can we monitor treatment using an HCV core antigen assay?, Diagn. Microbiol. Infect. Dis, 87, pp. 243-246, (2017)
  • [69] Cetiner S., Duran A.C., Kibar F., Yaman A., Performance comparison of new generation HCV core antigen test versus HCV RNA test in management of hepatitis C virus infection, Transfus. Apher. Sci, 56, pp. 362-366, (2017)
  • [70] Mohamed Z., Mbwambo J., Shimakawa Y., Poiteau L., Chevaliez S., Pawlotsky J.M., Rwegasha J., Bhagani S., Taylor-Robinson S.D., Makani J., Clinical utility of HCV core antigen detection and quantification using serum samples and dried blood spots in people who inject drugs in Dar-es-Salaam, Tanzania, J. Int. AIDS Soc, 20, (2017)
234567891011