Hepatitis C Virus-Core Antigen: Implications in Diagnostic, Treatment Monitoring and Clinical Outcomes

被引：0
作者：
Le, Duong Hoang Huy [1 ,2 ,3 ]
Kanokudom, Sitthichai [1 ,2 ]
Nguyen, Ha Minh [3 ,4 ]
Yorsaeng, Ritthideach [1 ]
Honsawek, Sittisak [2 ]
Vongpunsawad, Sompong [1 ]
Poovorawan, Yong [1 ,5 ]
机构：
[1] Chulalongkorn Univ, Fac Med, Ctr Excellence Clin Virol, Dept Pediat, Bangkok 10330, Thailand
[2] Chulalongkorn Univ, King Chulalongkorn Mem Hosp, Fac Med, Ctr Excellence Osteoarthritis & Musculoskeleton, Bangkok 10330, Thailand
[3] Pham Ngoc Thach Univ Med, Med Biochem & Mol Biol Dept, Fundamental Sci & Basic Med Sci, Ho Chi Minh City 700000, Vietnam
[4] Nguyen Tri Phuong Hosp, Lab Dept, Ho Chi Minh City 700000, Vietnam
[5] Royal Soc Thailand, Bangkok 10330, Thailand
来源：
VIRUSES-BASEL | 2024年 / 16卷 / 12期
关键词：
hepatitis C virus; HCV core antigen; diagnostics; HCV treatment; monitoring; resource-limited settings; global elimination strategies; DIRECT-ACTING ANTIVIRALS; HCV RNA; INFECTION; ASSAY; PROTEIN; MANAGEMENT; LIVER; QUANTIFICATION; PERFORMANCE; EXPRESSION;
D O I：
10.3390/v16121863
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The hepatitis C virus (HCV) infection, a global health concern, can lead to chronic liver disease. The HCV core antigen (HCVcAg), a viral protein essential for replication, offers a cost-effective alternative to HCV RNA testing, particularly in resource-limited settings. This review explores the significance of HCVcAg, a key protein in the hepatitis C virus, examining its structure, function, and role in the viral life cycle. It also evaluates its clinical use in diagnosis and treatment monitoring, comparing its performance to the standard HCV RNA assay using data from PubMed and Google Scholar. HCVcAg assays show high pooled sensitivity (93.5%) and pooled specificity (99.2%) compared to HCV RNA assays, correlating closely (r = 0.87) with HCV RNA levels. Hence, HCVcAg testing offers a cost-effective way to diagnose active HCV infections and monitor treatment, especially in resource-limited settings, but its sensitivity can vary and standardization is needed. HCVcAg also predicts liver disease progression and assesses liver damage risk, aiding patient management. It helps to identify patients at risk for fibrosis or carcinoma, making it vital in hepatitis C care. HCVcAg testing can expand access to HCV care, simplify management, and contribute to global elimination strategies, especially in low- and middle-income countries.
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页数：36
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  • [1] Li H., Lo S., Hepatitis C virus: Virology, diagnosis and treatment, World J. Hepatol, 7, (2015)
  • [2] Global Health Sector Strategies on, Respectively, HIV, Viral Hepatitis and Sexually Transmitted Infections for the Period 2022–2030, (2022)
  • [3] Pecoraro V., Banzi R., Cariani E., Chester J., Villa E., D'Amico R., Trenti T., New direct-acting antivirals for the treatment of patients with hepatitis C virus infection: A systematic review of randomized controlled trials, J. Clin. Exp. Hepatol, 9, pp. 522-538, (2019)
  • [4] Deniz M.T., Akhan S., Hepatitis C Virus Structure and Diagnostic Methods, Hepatitis C-Recent Advances, (2023)
  • [5] Roger S., Ducancelle A., Le Guillou-Guillemette H., Gaudy C., Lunel F., HCV virology and diagnosis, Clin. Res. Hepatol. Gastroenterol, 45, (2021)
  • [6] Okamoto H., Kojima M., Okada S.-I., Yoshizawa H., Iizuka H., Tanaka T., Muchmore E.E., Peterson D.A., Ito Y., Mishiro S., Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: Variability and stability, Virology, 190, pp. 894-899, (1992)
  • [7] Tsukiyama-Kohara K., Kohara M., Hepatitis C Virus: Viral Quasispecies and Genotypes, Int. J. Mol. Sci, 19, (2017)
  • [8] Sevvana M., Keck Z., Foung S.K., Kuhn R.J., Structural perspectives on HCV humoral immune evasion mechanisms, Curr. Opin. Virol, 49, pp. 92-101, (2021)
  • [9] Smith D.B., Bukh J., Kuiken C., Muerhoff A.S., Rice C.M., Stapleton J.T., Simmonds P., Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: Updated criteria and genotype assignment web resource, Hepatology, 59, pp. 318-327, (2014)
  • [10] Borgia S.M., Hedskog C., Parhy B., Hyland R.H., Stamm L.M., Brainard D.M., Subramanian M.G., McHutchison J.G., Mo H., Svarovskaia E., Identification of a novel hepatitis C virus genotype from Punjab, India: Expanding classification of hepatitis C virus into 8 genotypes, J. Infect. Dis, 218, pp. 1722-1729, (2018)
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