Thieno[3,2-b]pyrrole as a privileged scaffold in medicinal chemistry: An exploration of synthetic strategies and anticancer attributes

被引:0
作者
Goel, Kapil Kumar [1 ]
Lakhanpal, Sorabh [2 ]
Kumar, Roshan [3 ]
Prasad, K. Nagendra [4 ]
Dhiman, Sonia [5 ]
Kumar, Gaurav [6 ]
Singh, Damini [7 ]
Kumar, Bhupinder [8 ]
机构
[1] Gurukul Kangri Deemed Univ Haridwar, Dept Pharmaceut Sci, Pharmaceut Chem Div, Haridwar 249404, India
[2] Lovely Profess Univ, Div Res & Dev, Phagwara 144411, India
[3] Graph Era Deemed Univ, Dept Microbiol, Dehra Dun 248002, India
[4] KKR & KSR Inst Technol & Sci, Guntur, India
[5] Chitkara Univ, Ctr Res Impact & Outcome, Rajpura 140417, Punjab, India
[6] Chandigarh Univ, Univ Ctr Res & Dev, Mohali, Punjab, India
[7] IES Univ, IES Inst Technol & Management, Bhopal 462044, MP, India
[8] HNB Garhwal Univ, Dept Pharmaceut Sci, Chauras Campus, Srinagar 246174, Uttarakhand, India
关键词
Thieno[3; 2-b]pyrrole; Synthetic strategies; Anticancer derivatives; Drug development; SAR analysis; REVERSIBLE INHIBITORS; FUSED HETEROCYCLES; BIOLOGICAL EVALUATION; MOLECULAR DOCKING; DRUG; ANALOGS; DESIGN; THIOPHENE; TARGET; DERIVATIVES;
D O I
10.1016/j.molstruc.2024.139654
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Heterocyclic structural frameworks are the backbone of chemistry, especially in material and medicinal chemistry. Concerning medicinal chemistry, more than 75 % of approved drugs under clinical utilization or clinical investigations possess heterocyclic structural fragments. Thieno[3,2-b]pyrrole is a privileged heterocyclic pharmacophore with fused pyrrole and thiophene rings. The recent advancements in the synthetic methodologies and broad opportunities for structural alteration, thieno[3,2-b]pyrrole as a synthon has accelerated the interest of medicinal chemists toward utilization of this structural fragment in pharmacophores for the development of new anticancer drug candidates possessing high efficiency and specificity to diverse targets. The current report emphasizes the innumerable synthetic methodologies reported for synthesizing thieno[3,2-b]pyrroles, along with recent advancements and applications. We have discussed thieno[3,2-b]pyrroles' biological potential, focusing on anticancer potential and their SAR studies. We have also compiled a list of recently granted patents on thieno[3,2-b]pyrroles to various research groups. This study will assist in recognizing thieno[3,2-b]pyrrole derivatives that have high potency and efficacy as anticancer ligands, which can be identified for further clinical investigations to develop new drug molecules.
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页数:21
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