Gastrointestinal germinal center B cell depletion and reduction in IgA+ plasma cells in HIV-1 infection

被引：3

作者：

Cossarini, Francesca ^{[1
,2
]}

Shang, Joan ^{[2
,3
]}

Krek, Azra ^{[3
]}

Al-Taie, Zainab ^{[3
]}

Hou, Ruixue ^{[3
]}

Canales-Herrerias, Pablo ^{[2
,4
]}

Tokuyama, Minami ^{[2
,4
]}

Tankelevich, Michael ^{[2
,4
]}

Tillowitz, Adam ^{[2
,4
]}

Jha, Divya ^{[2
,4
]}

Livanos, Alexandra E. ^{[2
,4
]}

Leyre, Louise ^{[2
,4
]}

Uzzan, Mathieu ^{[2
,4
,5
]}

Martinez-Delgado, Gustavo ^{[2
,4
]}

Taylor, Matthew D. ^{[2
,4
]}

Sharma, Keshav ^{[2
,4
]}

Bourgonje, Arno R. ^{[2
,4
]}

Cruz, Michael ^{[3
]}

Ioannou, Giorgio ^{[2
,6
]}

Dawson, Travis ^{[2
,6
]}

D'Souza, Darwin ^{[2
,6
]}

Kim-Schulze, Seunghee ^{[2
,6
]}

Akm, Ahmed ^{[7
]}

Aberg, Judith A. ^{[1
]}

Chen, Benjamin K. ^{[1
,2
]}

Kwon, Douglas S. ^{[8
,9
]}

Gnjatic, Sacha ^{[2
,6
]}

Polydorides, Alexandros D. ^{[7
]}

Cerutti, Andrea ^{[2
,10
,11
]}

Argmann, Carmen ^{[3
]}

Vujkovic-Cvijin, Ivan ^{[12
]}

Suarez-Farinas, Mayte ^{[3
]}

Petralia, Francesca ^{[3
]}

Faith, Jeremiah J. ^{[2
,3
]}

Mehandru, Saurabh ^{[2
,4
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Med, Div Infect Dis, New York, NY USA

[2] Icahn Sch Med Mt Sinai, Precis Immunol Inst, New York, NY USA

[3] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY USA

[4] Icahn Sch Med Mt Sinai, Dept Med, Div Gastroenterol, New York, NY 10029 USA

[5] Hop Henri Mondor, APHP, Gastroenterol Dept, Creteil, France

[6] Icahn Sch Med Mt Sinai, Human Immune Monitoring Ctr, New York, NY USA

[7] Icahn Sch Med Mt Sinai, Dept Pathol Mol & Cell Based Med, New York, NY USA

[8] Ragon Inst MGH MIT & Harvard, Cambridge, MA USA

[9] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA USA

[10] Hosp del Mar Med Res Inst IMIM, Translat Clin Res Program, Barcelona, Spain

[11] Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain

[12] Cedars Sinai Med Ctr, F Widjaja IBD Inst, Div Gastroenterol, Dept Med, Los Angeles, CA USA

来源：

SCIENCE IMMUNOLOGY | 2024年 / 9卷 / 100期

关键词：

SYSTEMIC IMMUNE ACTIVATION; FOLLICULAR DENDRITIC CELLS; T-LYMPHOCYTE ACTIVATION; VIRUS TYPE-1 INFECTION; GUT MICROBIOTA; IMMUNOGLOBULIN-A; AFFINITY MATURATION; ANTIBODY-RESPONSES; IN-VIVO; MUCOSAL;

D O I：

10.1126/sciimmunol.ado0090

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Gastrointestinal (GI) B cells and plasma cells (PCs) are critical to mucosal homeostasis and the host response to HIV-1 infection. Here, high-resolution mapping of human B cells and PCs sampled from the colon and ileum during both viremic and suppressed HIV-1 infection identified a reduction in germinal center (GC) B cells and follicular dendritic cells (FDCs) during HIV-1 viremia. Immunoglobulin A-positive (IgA+) PCs are the major cellular output of intestinal GCs and were significantly reduced during viremic HIV-1 infection. PC-associated transcriptional perturbations, including type I interferon signaling, persisted in antiretroviral therapy (ART)-treated individuals, suggesting ongoing disruption of the intestinal immune milieu during ART. GI humoral immune perturbations were associated with changes in the intestinal microbiome composition and systemic inflammation. These findings highlight a key immune defect in the GI mucosa due to HIV-1 viremia.

引用

页数：19

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