M2 macrophage-derived exosomes reverse TGF-β1-induced epithelial mesenchymal transformation in BEAS-2B cells via the TGF-βRI/Smad2/3 signaling pathway

被引：0
|
作者：
Chao Liu [1 ]
Xiaolin Huang [2 ]
Siqi Li [1 ]
Wentao Ji [1 ]
Tian Luo [1 ]
Jianping Liang [1 ]
Yanhua Lv [3 ]
机构：
[1] Zhongshan People’s Hospital,Department of Respiratory and Critical Care Medicine
[2] Zhongshan Stomatological Hospital,Dental Implant and Restoration Centre
[3] Shunde Hospital,Department of Respiratory and Critical Care Medicine
[4] Southern Medical University (the First People’S Hospital of Shunde),undefined
来源：
European Journal of Medical Research | / 30卷 / 1期
关键词：
Macrophages; Exosomes; Epithelial mesenchymal transformation; Airway epithelial cells; Airway remodeling;
D O I：
10.1186/s40001-025-02516-4
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [1] M2 macrophages induce EMT through the TGF-/Smad2 signaling pathway
    Zhu, Liangying
    Fu, Xiao
    Chen, Xiang
    Han, Xiaodong
    Dong, Ping
    CELL BIOLOGY INTERNATIONAL, 2017, 41 (09) : 960 - 968
  • [2] M2 macrophage-derived exosomes carry miR-142-3p to restore the differentiation balance of irradiated BMMSCs by targeting TGF-β1
    Huang, Chong
    Zhao, Lu
    Xiao, Yun
    Tang, Zihao
    Jing, Li
    Guo, Kai
    Tian, Lei
    Zong, Chunlin
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2024, 479 (04) : 993 - 1010
  • [3] M2 macrophage-derived exosomes carry miR-142-3p to restore the differentiation balance of irradiated BMMSCs by targeting TGF-β1
    Chong Huang
    Lu Zhao
    Yun Xiao
    Zihao Tang
    Li Jing
    Kai Guo
    Lei Tian
    Chunlin Zong
    Molecular and Cellular Biochemistry, 2024, 479 : 993 - 1010
  • [4] Exosomes derived from mesenchymal stem cells reverse EMT via TGF-β1/Smad pathway and promote repair of damaged endometrium
    Yuan Yao
    Ran Chen
    Guowu Wang
    Yu Zhang
    Fang Liu
    Stem Cell Research & Therapy, 10
  • [5] Exosomes derived from mesenchymal stem cells reverse EMT via TGF-β1/Smad pathway and promote repair of damaged endometrium
    Yao, Yuan
    Chen, Ran
    Wang, Guowu
    Zhang, Yu
    Liu, Fang
    STEM CELL RESEARCH & THERAPY, 2019, 10 (1)
  • [6] FOXC1 promotes EMT and colorectal cancer progression by attracting M2 macrophages via the TGF-β/Smad2/3/snail pathway
    Zhang, Haoran
    Nie, Jinlin
    Bao, Zhen
    Shi, Yangdong
    Gong, Jin
    Li, Hailiang
    CELLULAR SIGNALLING, 2025, 130
  • [7] The role of macrophage-derived TGF-β1 on SiO2-induced pulmonary fibrosis: A review
    Zhang, Zhao-qiang
    Tian, Hai-tao
    Liu, Hu
    Xie, Ruining
    TOXICOLOGY AND INDUSTRIAL HEALTH, 2021, 37 (04) : 240 - 250
  • [8] Ochratoxin A treated rat derived urinary exosomes enhanced cell growth and extracellular matrix production in normal kidney cells through modulation of TGF-β1/smad2/3 signaling pathway
    Dev, Indra
    Pal, Saurabh
    Lugun, Onila
    Singh, Neha
    Ansari, Kausar Mahmood
    LIFE SCIENCES, 2022, 298
  • [9] The Interaction of OTUB1 and TRAF3 Mediates NLRP3 Inflammasome Activity to Regulate TGF-β1-induced BEAS-2B Cell Injury
    Shang, Liqun
    Du, Yujie
    Zhao, Yali
    Zhang, Yongqing
    Liu, Cuicui
    APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2023, 195 (11) : 7060 - 7074
  • [10] The Interaction of OTUB1 and TRAF3 Mediates NLRP3 Inflammasome Activity to Regulate TGF-β1-induced BEAS-2B Cell Injury
    Liqun Shang
    Yujie Du
    Yali Zhao
    Yongqing Zhang
    Cuicui Liu
    Applied Biochemistry and Biotechnology, 2023, 195 : 7060 - 7074
12345